Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
A longitudinal study of antibodies to the Plasmodium falciparum antigen Pf155/RESA and immunity to malaria infection in adult Liberians
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 84, No. 3, Year 1990
Notification
URL copied to clipboard!
Description
118 adult Liberians from 2 villages were studied prospectively for one year with monthly blood examinations for malaria parasites. The crude parasite rate was 41η5% and the crude gametocyte rate was 6η1%. The inoculation rate varied between 0η075 in the dry season and almost 0η4 in the rainy season, which is in accordance with other data from holoendemic areas. 47η5% (56) had a titre to the Pf155/RESA antigen ≤1/50(‘low responders’) and 52η5% (62) had a titre of ≥1/250 (‘high responders’). The response was not age-dependent in this adult population, which may suggest that genetic factors are determining whether the individual become a high or low responder. Antibodies against the Pf155/RESA antigen were measured in 2 surveys 8 months apart, and the mean antibody response to Pf155/RESA and its EENV sequence was constant without seasonal variation. Pf155/RESA high responders had lower parasite densities during all 3 seasons surveyed, and Pf155/RESA high responders, with high antibody reactivity against the (EENV)6 sequence from the 3' repeat region of Pf155/RESA, had significantly lower parasite densities in the rainy season of 1987. The data suggest that high titres of antibodies to the Pf155/RESA antigen, and especially to its EENV sequence, might play a role in protective immunity in adults. © 1990, Royal Society of Tropical Medicine and Hygiene. All rights reserved.
Authors & Co-Authors
Petersen, Eskild
Liberia, Monrovia
Liberian Institute for Biomedical Research
Sweden, Stockholm
Karolinska Institutet
Högh, Birthe
Liberia, Monrovia
Liberian Institute for Biomedical Research
Sweden, Stockholm
Stockholms Universitet
Marbiah, Nuahn T.
Liberia, Monrovia
Liberian Institute for Biomedical Research
Perlmann, Hedvig K.
Sweden, Stockholm
Stockholms Universitet
Willcox, Michael C.
Sweden
Gävle Central Hospital
Dolopaie, E.
Liberia, Monrovia
Liberian Institute for Biomedical Research
Hanson, A. P.
Liberia, Monrovia
Liberian Institute for Biomedical Research
Bjǒrkman, Anders B.
Sweden, Stockholm
Karolinska Institutet
Perlmann, Peter H.
Sweden, Stockholm
Stockholms Universitet
Statistics
Citations: 42
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1016/0035-9203(90)90307-Z
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative