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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Effect of the initial dose of foot-and-mouth disease virus on the early viral dynamics within pigs
Journal of the Royal Society Interface, Volume 6, No. 39, Year 2009
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Description
This paper investigates the early viral dynamics of foot-and-mouth disease (FMD) within infected pigs. Using an existing within-host model, we investigate whether individual variation can be explained by the effect of the initial dose of FMD virus. To do this, we consider the experimental data on the concentration of FMD virus genomes in the blood (viral load). In this experiment, 12 pigs were inoculated with one of three different doses of FMD virus: low; medium; or high. Measurements of the viral load were recorded over a time course of approximately 11 days for every 8 hours. The model is a set of deterministic differential equations with the following variables: viral load; virus in the interstitial space; and the proportion of epithelial cells available for infection, infected and uninfected. The model was fitted to the data for each animal individually and also simultaneously over all animals varying only the initial dose. We showthat the general trend in the data can be explained by varying only the initial dose. The higher the initial dose the earlier the development of a detectable viral load. © 2008 The Royal Society.
Authors & Co-Authors
Quan, Melvyn
United Kingdom, Surrey
The Pirbright Institute
Savill, Nicholas Jon
United Kingdom, Edinburgh
The University of Edinburgh
Matthews, Louise
United Kingdom, Glasgow
University of Glasgow
Alexandersen, Soren
Canada, Ottawa
Government of Canada
Woolhouse, Mark E.J.
United Kingdom, Edinburgh
The University of Edinburgh
Statistics
Citations: 20
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1098/rsif.2008.0434
ISSN:
17425689
Study Approach
Quantitative