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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The metabolic syndrome as a predictor of incident diabetes mellitus in Mauritius
Diabetic Medicine, Volume 24, No. 12, Year 2007
Notification
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Description
Aims: To assess the utility of the metabolic syndrome (MetS) and a Diabetes Predicting Model as predictors of incident diabetes. Methods: A longitudinal survey was conducted in Mauritius in 1987 (n = 4972; response 80%) and 1992 (n = 3685; follow-up 74.2%). Diabetes status was retrospectively determined using 1999 World Health Organization (WHO) criteria. MetS was determined according to four definitions and sensitivity, positive predictive value (PPV), specificity and the association with incident diabetes before and after adjustment for MetS components calculated. Results: Of the 3198 at risk, 297 (9.2%) developed diabetes between 1987 and 1992. The WHO MetS definition had the highest prevalence (20.3%), sensitivity (42.1%) and PPV (26.8%) for prediction of incident diabetes, the strongest association with incident diabetes after adjustment for age and sex [odds ratio 4.6 (3.5-6.0)] and was the only definition to show a significant association after adjustment for its component parts (in men only). The low prevalence and sensitivity of the International Diabetes Federation (IDF) and ATPIII MetS definitions resulted from waist circumference cut-points that were high for this population, particularly in men, and both were not superior to a diabetes predicting model on receiver operating characteristic analysis. Conclusions: Of the MetS definitions tested, the WHO definition best identifies those who go on to develop diabetes, but is not often used in clinical practice. If cut-points or measures of obesity appropriate for this population were used, the IDF and ATPIII MetS definitions could be recommended as useful tools for prediction of diabetes, given their relative simplicity. © 2007 International Diabetes Institute.
Authors & Co-Authors
Cameron, Adrian J.
Australia, Melbourne
Baker Heart and Diabetes Institute
Zimmet, Paul Z.
Australia, Melbourne
Baker Heart and Diabetes Institute
Söderberg, Stefan
Sweden, Umea
Umeå Universitet
Alberti, Kurt George M.M.A.
United Kingdom, Newcastle
Newcastle University
Sicree, Richard A.
Australia, Melbourne
Baker Heart and Diabetes Institute
Tuomilehto, Jaakko O.I.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Finland, Helsinki
Helsingin Yliopisto
Chitson, Pierrot
Mauritius, Port Louis
Ministry of Health and Quality of Life
Shaw, Jonathan E.
Australia, Melbourne
Baker Heart and Diabetes Institute
Statistics
Citations: 37
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1111/j.1464-5491.2007.02288.x
ISSN:
07423071
e-ISSN:
14645491
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Study Approach
Quantitative
Study Locations
Mauritius
Participants Gender
Male