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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Effect of a lifestyle intervention on weight change in south Asian individuals in the UK at high risk of type 2 diabetes: A family-cluster randomised controlled trial
The Lancet Diabetes and Endocrinology, Volume 2, No. 3, Year 2014
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Description
Background: The susceptibility to type 2 diabetes of people of south Asian descent is established, but there is little trial-based evidence for interventions to tackle this problem. We assessed a weight control and physical activity intervention in south Asian individuals in the UK. Methods: We did this non-blinded trial in two National Health Service (NHS) regions in Scotland (UK). Between July 1, 2007, and Oct 31, 2009, we recruited men and women of Indian and Pakistani origin, aged 35 years or older, with waist circumference 90 cm or greater in men or 80 cm or greater in women, and with impaired glucose tolerance or impaired fasting glucose determined by oral glucose tolerance test. Families were randomised (using a random number generator program, with permuted blocks of random size, stratified by location [Edinburgh or Glasgow], ethnic group [Indian or Pakistani], and number of participants in the family [one vs more than one]) to intervention or control. Participants in the same family were not randomised separately. The intervention group received 15 visits from a dietitian over 3 years and the control group received four visits in the same period. The primary outcome was weight change at 3 years. Analysis was by modified intention to treat, excluding participants who died or were lost to follow-up. We used linear regression models to provide mean differences in baseline-adjusted weight at 3 years. This trial is registered, number ISRCTN25729565. Findings: Of 1319 people who were screened with an oral glucose tolerance test, 196 (15%) had impaired glucose tolerance or impaired fasting glucose and 171 entered the trial. Participants were in 156 family clusters that were randomised (78 families with 85 participants were allocated to intervention; 78 families with 86 participants were allocated to control). 167 (98%) participants in 152 families completed the trial. Mean weight loss in the intervention group was 1·13 kg (SD 4·12), compared with a mean weight gain of 0·51 kg (3·65) in the control group, an adjusted mean difference of -1·64 kg (95% CI -2·83 to -0·44). Interpretation: Modest, medium-term changes in weight are achievable as a component of lifestyle-change strategies, which might control or prevent adiposity-related diseases. Funding: National Prevention Research Initiative, NHS Research and Development; NHS National Services Scotland NHS Health Scotland. © 2014 Bhopal et al.
Authors & Co-Authors
Bhopal, Raj Singh
United Kingdom, Edinburgh
The University of Edinburgh
Douglas, Anne F.
United Kingdom, Edinburgh
The University of Edinburgh
Wallia, Sunita
United Kingdom, Edinburgh
The University of Edinburgh
Forbes, John F.
United Kingdom, Edinburgh
The University of Edinburgh
Lean, Michael E.J.
United Kingdom, Glasgow
University of Glasgow
Gill, Jason M.r.
United Kingdom, Glasgow
University of Glasgow
McKnight, John A.
United Kingdom, Edinburgh
Western General Hospital
Sattar, Naveed A.
United Kingdom, Glasgow
University of Glasgow
Sheikh, Aziz
United Kingdom, Edinburgh
The University of Edinburgh
United States, Boston
Brigham and Women's Hospital
Wild, Sarah Helen
United Kingdom, Edinburgh
The University of Edinburgh
Tuomilehto, Jaakko O.I.
Austria, Krems an Der Donau
Donau-universität Krems
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Saudi Arabia, Jeddah
King Abdulaziz University
Sharma, Anu
United Kingdom, Edinburgh
The University of Edinburgh
Bhopal, Ruby
United Kingdom, Edinburgh
The University of Edinburgh
Smith, Joel B.E.
United Kingdom, Edinburgh
Edinburgh Medical School
Butcher, Isabella
United Kingdom, Edinburgh
The University of Edinburgh
Murray, Gordon D.
United Kingdom, Edinburgh
The University of Edinburgh
Statistics
Citations: 126
Authors: 16
Affiliations: 8
Identifiers
Doi:
10.1016/S2213-8587(13)70204-3
ISSN:
22138587
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Randomised Control Trial
Cohort Study
Participants Gender
Male
Female