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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Observational study of regional aortic size referenced to body size: Production of a cardiovascular magnetic resonance nomogram
Journal of Cardiovascular Magnetic Resonance, Volume 16, No. 1, Article 9, Year 2014
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Description
Background: Cardiovascular magnetic resonance (CMR) is regarded as the gold standard for clinical assessment of the aorta, but normal dimensions are usually referenced to echocardiographic and computed tomography data and no large CMR normal reference range exists. As a result we aimed to 1) produce a normal CMR reference range of aortic diameters and 2) investigate the relationship between regional aortic size and body surface area (BSA) in a large group of healthy subjects with no vascular risk factors. Methods. 447 subjects (208 male, aged 19-70 years) without identifiable cardiac risk factors (BMI range 15.7-52.6 kg/m§ssup§2§esup§) underwent CMR at 1.5 T to determine aortic diameter at three levels: the ascending aorta (Ao) and proximal descending aorta (PDA) at the level of the pulmonary artery, and the abdominal aorta (DDA), at a level 12 cm distal to the PDA. In addition, 201 of these subjects had aortic root imaging, allowing for measurements at the level of the aortic valve annulus (AV), aortic sinuses and sinotubular junction (STJ). Results: Normal diameters (mean ±2 SD) were; AV annulus male(♂) 24.4 ± 5.4, female (♀) 21.0 ± 3.6 mm, aortic sinus♂32.4 ± 7.7, ♀27.6 ± 5.8 mm, ST-junction ♂25.0 ± 7.4, ♀21.8 ± 5.4 mm, Ao ♂26.7 ± 7.7, ♀25.5 ± 7.4 mm, PDA ♂20.6 ± 5.6, +18.9 ± 4.0 mm, DDA ♂17.6 ± 5.1, ♀16.4 ± 4.0 mm. Aortic root and thoracic aortic diameters increased at all levels measured with BSA. No gender difference was seen in the degree of dilatation with increasing BSA (p > 0.5 for all analyses). Conclusion: Across both genders, increasing body size is characterized by a modest degree of aortic dilatation, even in the absence of traditional cardiovascular risk factors. © 2014 Davis et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Lewandowski, Adam James
United Kingdom, Oxford
University of Oxford
Holloway, Cameron J.
Australia, Sydney
Victor Chang Cardiac Research Institute
Ntusi, Ntobeko A.B.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Banerjee, Rajarshi
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Nethononda, Richard M.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Francis, Jane M.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Myerson, Saul G.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Leeson, Paul C.
United Kingdom, Oxford
University of Oxford
Neubauer, Stefan
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Rider, Oliver J.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Statistics
Citations: 70
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1186/1532-429X-16-9
ISSN:
1532429X
Research Areas
Noncommunicable Diseases
Participants Gender
Male
Female