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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Differential antibody responses to Plasmodium falciparum invasion ligand proteins in individuals living in malaria-endemic areas in Brazil and Cameroon
American Journal of Tropical Medicine and Hygiene, Volume 77, No. 5, Year 2007
Notification
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Description
Antibody responses to malaria invasion ligands and proteins on the merozoite surface have been shown to interfere with red cell invasion and correlate with immunity to malaria. The current study is the first to characterize the antibody responses to EBA-140 and EBA-181, Plasmodium falciparum invasion ligands implicated in the alternative pathways of invasion, in age-matched populations of individuals living in endemic areas in both Brazil and Cameroon. Antibody responses to the proteins screened were different between populations. The African individuals reacted strongly with most fragments of these two EBAs, while the majority of the individuals from Mato Grosso, Brazil, reacted weakly and those from the Amazon had elevated responses to these EBA proteins. When compared with the responses against MSP-1 19 and EBA-175, it appeared that the Brazilian population has a variable ability to recognize P. falciparum invasion ligand proteins and that these responses are distinct from the African population. Copyright © 2007 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Ford, Louise
United States, New York
New York Blood Center
Lobo, Cheryl A.
United States, New York
New York Blood Center
Rodriguez, Marilis
United States, New York
New York Blood Center
Zalis, Mariano G.
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
Machado, Ricardo L.D.
Brazil, Sao Jose do Rio Preto
Faculty of Medicine of São José do Rio Preto
Rossit, Andréa R.B.
Brazil, Sao Jose do Rio Preto
Faculty of Medicine of São José do Rio Preto
Cavasini, Carlos E.
Brazil, Sao Jose do Rio Preto
Faculty of Medicine of São José do Rio Preto
Couto, Alvaro A.R.
Brazil, Amapa
Seama Faculty
Enyong, Peter Ayuk I.
Cameroon
Tropical Medicine Research Station
Lustigman, Sara
United States, New York
New York Blood Center
Statistics
Citations: 21
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.4269/ajtmh.2007.77.977
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Cameroon