Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Combined food and micronutrient supplements during pregnancy have limited impact on child blood pressure and kidney function in rural Bangladesh
Journal of Nutrition, Volume 143, No. 5, Year 2013
Notification
URL copied to clipboard!
Description
Observational evidence suggests nutritional exposures during in utero developmentmay have long-lasting consequences for health; data from interventions are scarce. Here, we present a trial follow-up study to assess the association between prenatal food and micronutrient supplementation and childhood blood pressure and kidney function. During the MINIMat Trial in rural Bangladesh, women were randomly assigned early in pregnancy to receive an early or later invitation to attend a food supplementation program and additionally to receive either iron and folate or multiple micronutrient tablets daily. The 3267 singleton birth individualswith measured anthropometry born during the trial were eligible for a follow-up study at 4.5 y old. A total of 77% of eligible individuals were recruited and blood pressure, kidney size by ultrasound, and glomerular filtration rate (GFR; calculated from plasma cystatin c) were assessed. In adjusted analysis, early invitation to food supplementation was associated with a 0.72-mmHg [(95%CI: 0.16, 1.28); P = 0.01] lower childhood diastolic blood pressure and maternal MMS supplementation was associated with a marginally higher [0.87 mm Hg (95% CI: 0.18, 1.56); P = 0.01] childhood diastolic blood pressure. There was also some evidence that a supplement higher in iron was associated with a higher offspring GFR. No other effects of the food ormicronutrient interventionswere observed and therewas no interaction between the interventions on the outcomes studied. These marginal associations and small effect sizes suggest limited public health importance in early childhood. © 2013 American Society for Nutrition.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3970319/bin/supp_143_5_728__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3970319/bin/jn.112.168518_nutrition168518SupplementaryData.pdf
Authors & Co-Authors
Hawkesworth, Sophie
United Kingdom, London
London School of Hygiene & Tropical Medicine
Wagatsuma, Yukiko
Japan, Tsukuba
University of Tsukuba
Hawlader, Mohammad Delwer Hossain
Japan, Tsukuba
University of Tsukuba
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Fulford, Anthony J.C.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Arifeen, Shams E.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Persson, Lars Åke Å.
Sweden, Uppsala
Uppsala Universitet
Moore, Sophie E.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Statistics
Citations: 30
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.3945/jn.112.168518
ISSN:
15416100
Research Areas
Food Security
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Female