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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
HIGH PREVALENCE OF PENICILLIN-INSENSITIVE PNEUMOCOCCI IN PORT MORESBY, PAPUA NEW GUINEA
The Lancet, Volume 316, No. 8187, Year 1980
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Description
One-third of 57 strains of pneumococci isolated from patients with severe pneumococcal infections in Port Moresby, Papua New Guinea, in 1978 were penicillin-insensitive (PR). The infections were community-acquired and comprised cases of bacteræmia, bacteræmic pneumonia, and meningitis. The prevalence of invasive PR strains in children was significantly greater than in adults. Twenty-one serotypes were identified, of which ten types (6, 9, 10, 12-14, 18, 19, 23, 24) showed diminished sensitivity to penicillin; with types 12 and 18 penicillin-insensitivity has not been met with previously in Papua New Guinea and only rarely elsewhere; seven of the 19 PR strains belonged to type 6. Amongst insensitive strains, minimum inhibitory concentrations of penicillin G ranged from 0·1 to 1·0 μg/ml (resistance ratios 5 to 50). Resistance to chloramphenicol and other antimicrobial drugs was not encountered. © 1980, All rights reserved.
Authors & Co-Authors
Gratten, Michael J.
United Kingdom
Port Moresby General Hospital
Naraqi, S.
Guinea
University of Papua
Hansman, David J.
Australia, Adelaide
Women's and Children's Hospital Adelaide
Statistics
Citations: 50
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1016/S0140-6736(80)90072-0
ISSN:
01406736
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Guinea