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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Isolation and structure elucidation of izuminosides A-C: A rare phenazine glycosides from Streptomyces sp. IFM 11260
Journal of Antibiotics, Volume 64, No. 3, Year 2011
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Description
Three new glycosylated phenazine derivatives, named izuminosides A-C (1-3) have been isolated from the ethyl acetate extract of Streptomyces sp. IFM 11260. The structures of the new compounds were determined on the basis of their spectral data. Compounds 1-3 were evaluated for their activity in overcoming tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance in human gastric adenocarcinoma cells. Compounds 2 (10 μM) and 3 (60 μM) in combination with TRAIL showed synergistic activity in sensitizing TRAIL-resistance AGS cells. © 2011 Japan Antibiotics Research Association All rights reserved.
Authors & Co-Authors
Abdelfattah, Mohamed Saleh Hamed
Japan, Chiba
Chiba University
Egypt, Helwan
Faculty of Science
Toume, Kazufumi
Japan, Chiba
Chiba University
Ishibashi, Masami
Japan, Chiba
Chiba University
Statistics
Citations: 29
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1038/ja.2010.172
e-ISSN:
18811469
Research Areas
Cancer