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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Emerging roles of L-type voltage-gated and other calcium channels in T lymphocytes
Frontiers in Immunology, Volume 4, No. AUG, Article Article 243, Year 2013
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Description
In T lymphocytes, calcium ion controls a variety of biological processes including development, survival, proliferation, and effector functions. These distinct and specific roles are regulated by different calcium signals, which are generated by various plasma membrane calcium channels. The repertoire of calcium-conducting proteins in T lymphocytes includes store-operated CRAC channels, transientreceptor potential channels, P2X channels, and L-type voltage-gated calcium (Cav1) channels. In this paper, we will focus mainly on the role of the Cav1 channels found expressed by T lymphocytes, where these channels appear to operate in a T cell receptor stimulation-dependent and voltage sensor independent manner. We will review their expression profile at various differentiation stages of CD4 and CD8 T lymphocytes. Then, we will present crucial genetic evidence in favor of a role of these Cav1 channels and related regulatory proteins in both CD4 and CD8 T cell functions such as proliferation, survival, cytokine production, and cytolysis. Finally, we will provide evidence and speculate on how these voltage-gated channels might function in the T lymphocyte, a non-excitable cell. © 2013 Badou, Jha, Matza and Flavell.
Authors & Co-Authors
Badou, Abdallah
Morocco, Marakech
Université Cadi Ayyad
Jha, Mithilesh Kumar
United States, Saranac Lake
Trudeau Institute
Matza, Didi
Israel, Jerusalem
Hadassah University Medical Centre
Flavell, Richard A.
United States, New Haven
Yale School of Medicine
United States, Chevy Chase
Howard Hughes Medical Institute
Statistics
Citations: 75
Authors: 4
Affiliations: 5
Identifiers
Doi:
10.3389/fimmu.2013.00243
e-ISSN:
16643224
Research Areas
Genetics And Genomics