Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Neutralizing antibodies generated during natural hiv-1 infection: Good news for an hiv-1 vaccine?
Nature Medicine, Volume 15, No. 8, Year 2009
Notification
URL copied to clipboard!
Description
Most existing viral vaccines generate antibodies that either block initial infection or help eradicate the virus before it can cause disease. For HIV-1, obstacles to eliciting protective neutralizing antibodies (NAbs) have often seemed insurmountable. The target of HIV-specific NAbs, the viral envelope glycoprotein (Env), is highly variable in amino acid sequence and glycosylation pattern. Conserved elements of HIV-1 Env seem to be poorly immunogenic, and previous attempts to generate broadly reactive NAbs by vaccination have proven ineffective. However, recent studies show that antibodies in the sera of some HIV-1-infected individuals can neutralize diverse HIV-1 isolates. Detailed analyses of these sera provide new insights into the viral epitopes targeted by broadly reactive NAbs. The findings discussed here suggest that the natural NAb response to HIV-1 can inform future vaccine design. A concerted effort of structure-based vaccine design will help guide the development of improved antibody-based vaccines for HIV-1. © 2009 Macmillan Publishers Limited. All rights reserved.
Authors & Co-Authors
Stamatatos, Leonidas L.
United States, Seattle
Seattle Biomedical Research Institute
United States, Seattle
University of Washington
Morris, Lynn
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Johannesburg
South Africa Research Organization
Burton, Dennis Raymond
United States, San Diego
Scripps Research Institute
Mascola, John R.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Statistics
Citations: 476
Authors: 4
Affiliations: 6
Identifiers
Doi:
10.1038/nm.1949
ISSN:
10788956
e-ISSN:
1546170X
Research Areas
Infectious Diseases