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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
The effect of Aloe vera A. Berger (Liliaceae) on gastric acid secretion and acute gastric mucosal injury in rats
Journal of Ethnopharmacology, Volume 93, No. 1, Year 2004
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Description
The effect of varying doses of ethanol extract of Aloe vera (Liliaceae) on acute gastric mucosal lesions induced by 0.6 M HCl and acid output was studied in the pylorus ligated and lumen perfuse rats, respectively. Acid secretion was determined by titration of the collected gastric juice to pH 7.0. Intraperitoneal injection of Aloe vera, dose dependently inhibited gastric acid secretion. The plant was more active as a gastroprotective agent at lower concentration against mucosal injury induced by 0.6 M HCl. In conclusion, Aloe vera is endowed with gastric acid anti-secretory activity and could protect the gastric mucosa at low concentrations against injurious agents. © 2004 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Yusuf, Sadiq A.
Nigeria, Zaria
Ahmadu Bello University
Agunu, A.
Nigeria, Zaria
Ahmadu Bello University
Diana, Mshelia
Nigeria, Zaria
Ahmadu Bello University
Statistics
Citations: 79
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.1016/j.jep.2004.03.027
ISSN:
03788741
Research Areas
Violence And Injury