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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Relationship of thyroid function with obesity and type 2 diabetes in euthyroid tunisian subjects
Endocrine Research, Volume 38, No. 1, Year 2013
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Description
Objectives. Although a relationship between obesity and metabolic consequences with thyroid function has been reported, the underlying pathogenesis is not completely known. In the current study, we evaluated the thyroid function in obese and/or diabetic patients compared to healthy normal weight peers, exploring the possible association between components of metabolic syndrome and thyroid function parameters. Methods. We recruited 108 subjects (56 male and 52 female). In all subjects, thyroid stimulating hormone (TSH), free thyroxine (FT4), fasting plasma levels of insulin and glucose, homeostasis model assessment for insulin resistance, and obesity parameters were assessed. Results. We found that circulating levels of TSH and FT4 were significantly increased in overweight and obese subjects. However, the data do not reveal any change of these hormones in diabetics. Multivariate linear regression analysis showed that TSH was directly associated with both obesity and insulin resistance parameters (p < 0.05). FT4 was negatively associated only with obesity parameters (p < 0.05). Conclusions. Our data strongly support that the changes of thyroid hormones may be influenced by adiposity and its metabolic consequences, such as insulin resistance. This relationship can be explained by a cross talk between adipose tissue release and thyroid function. Nevertheless, metformin treatment seems to affect thyroid function in diabetic patients by maintaining plasma thyrotropin levels to subnormal levels. © 2013 Informa Healthcare USA, Inc.
Authors & Co-Authors
Kouidhi, Soumaya
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Berhouma, Rym
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Ammar, Myriam
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Rouissi, Kamel
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Jarboui, Slim
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Clerget-Froidevaux, Marie Stéphanie
France, Paris
Diversité Moléculaire
Seugnet, Isabelle
France, Paris
Diversité Moléculaire
Abid, Hafawa Kammoun
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Bchir, Fattouma
Tunisia, Tunis
Institut Pasteur de Tunis
Demeneix, Barbara A.
France, Paris
Diversité Moléculaire
Guissouma, Hajer
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Elgaâïed, Amel Benammar A.
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Statistics
Citations: 30
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.3109/07435800.2012.699987
e-ISSN:
15324206
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Approach
Quantitative
Participants Gender
Male
Female