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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Viral antibody dynamics in a chiropteran host
Journal of Animal Ecology, Volume 83, No. 2, Year 2014
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Description
Bats host many viruses that are significant for human and domestic animal health, but the dynamics of these infections in their natural reservoir hosts remain poorly elucidated. In these, and other, systems, there is evidence that seasonal life-cycle events drive infection dynamics, directly impacting the risk of exposure to spillover hosts. Understanding these dynamics improves our ability to predict zoonotic spillover from the reservoir hosts. To this end, we followed henipavirus antibody levels of >100 individual E. helvum in a closed, captive, breeding population over a 30-month period, using a powerful novel antibody quantitation method. We demonstrate the presence of maternal antibodies in this system and accurately determine their longevity. We also present evidence of population-level persistence of viral infection and demonstrate periods of increased horizontal virus transmission associated with the pregnancy/lactation period. The novel findings of infection persistence and the effect of pregnancy on viral transmission, as well as an accurate quantitation of chiropteran maternal antiviral antibody half-life, provide fundamental baseline data for the continued study of viral infections in these important reservoir hosts. © 2013 The Authors. Journal of Animal Ecology © 2013 British Ecological Society.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4413793/bin/JANE-83-415-s001.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC4413793/bin/JANE-83-415-s002.pdf
Authors & Co-Authors
Baker, Kate Susan
United Kingdom, Cambridge
University of Cambridge
United Kingdom, London
Zoological Society of London Institute of Zoology
United Kingdom, Hinxton
Wellcome Sanger Institute
Suu-Ire, Richard Dery
Ghana, Accra
Forestry Commission
Barr, Jennifer A.
Australia, Canberra
Commonwealth Scientific and Industrial Research Organisation
Hayman, David T.S.
United States, Fort Collins
Colorado State University
Broder, Christopher C.
United States, Bethesda
Uniformed Services University of the Health Sciences
Horton, Daniel L.
United Kingdom, Addlestone
Animal and Plant Health Agency
Durrant, Christopher
United Kingdom, London
Zoological Society of London Institute of Zoology
Murcia, Pablo R.
United Kingdom, Glasgow
University of Glasgow
Cunningham, Andrew Alexander
United Kingdom, London
Zoological Society of London Institute of Zoology
WOOD, JAMES L.N.
United Kingdom, Cambridge
University of Cambridge
Statistics
Citations: 44
Authors: 10
Affiliations: 9
Identifiers
Doi:
10.1111/1365-2656.12153
e-ISSN:
13652656
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study