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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Longitudinal analysis of antibody responses to trachoma antigens before and after mass drug administration
BMC Infectious Diseases, Volume 14, No. 1, Article 3154, Year 2014
Notification
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Description
Background: Blinding trachoma, caused by the bacteria Chlamydia trachomatis, is a neglected tropical disease targeted for elimination by 2020. A major component of the elimination strategy is mass drug administration (MDA) with azithromycin. Currently, program decisions are made based on clinical signs of ocular infection, but we have been investigating the use of antibody responses for post-MDA surveillance. In a previous study, IgG responses were detected in children lacking clinical evidence of trachoma, suggesting that IgG responses represented historical infection. To explore the utility of serology for program evaluation, we compared IgG and IgA responses to trachoma antigens and examined changes in IgG and IgA post-drug treatment.Methods: Dried blood spots and ocular swabs were collected with parental consent from 264 1-6 year olds in a single village of Kongwa District, central Tanzania. Each child also received an ocular exam for detection of clinical signs of trachoma. MDA was given, and six months later an additional blood spot was taken from these same children. Ocular swabs were analyzed for C. trachomatis DNA and antibody responses for IgA and total IgG were measured in dried bloods spots.Results: Baseline antibody responses showed an increase in antibody levels with age. By age 6, the percentage positive for IgG (96.0%) was much higher than for IgA (74.2%). Antibody responses to trachoma antigens declined significantly six months after drug treatment for most age groups. The percentage decrease in IgA response was much greater than for IgG. However, no instances of seroreversion were observed.Conclusions: Data presented here suggest that focusing on concordant antibody responses in children will provide the best serological surveillance strategy for evaluation of trachoma control programs. © 2014 Goodhew et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Goodhew, Brook
United States, Atlanta
Centers for Disease Control and Prevention
Morgan, Sheri Maria G.
United States, Columbus
The Ohio State University
Switzer, Andrew J.
United States, Northfield
St. Olaf College
Muñoz, Beatriz E.
United States, Baltimore
Wilmer Eye Institute
Dize, Laura
United States, Baltimore
Johns Hopkins University
Gaydos, Charlotte Ann
United States, Baltimore
Johns Hopkins University
Mkocha, Harran A.
Tanzania, Kongwa
Kongwa Trachoma Project
Vos, Theo K.
United States, Baltimore
Wilmer Eye Institute
Wiegand, Ryan E.
United States, Atlanta
Centers for Disease Control and Prevention
Lammie, Patrick J.
United States, Atlanta
Centers for Disease Control and Prevention
Martin, Diana L.
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 43
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1186/1471-2334-14-216
e-ISSN:
14712334
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Tanzania