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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
HLA‐antigens in oral submucous fibrosis
Journal of Oral Pathology & Medicine, Volume 23, No. 1, Year 1994
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Description
HLA–typing was carried out on 122 areca nut chewers who attended hospitals for complaints unrelated to the habit. The subjects were South Africans of Indian extraction. The study did not include haplotypes. Palpable fibrous bands in the mouth indicated oral submucous fibrosis. The subjects were divided into 4 groups based on specific oral symptoms and signs. Groups A and B were without fibrous bands. Group A (47 subjects) included those with one or no symptoms while group B (28 subjects) suffered from 2 to 7 oral symptoms. Group C (17 subjects) had oral symptoms and represented early or mild oral submucous fibrosis and exhibited at least one discrete palpable fibrous hand. Group D (30 subjects) were classic oral submucous fibrosis cases with multiple bands. The high occurrence of oral submucous fibrosis in this study group (39%) is similar to the occurrence in comparable age groups reported earlier–n South Africa and is conceivably due to the higher age range of the subjects and their relatively long exposure to the area nut. We were unable to demonstrate a specific pattern of HLA–antigen frequencies in chewers with or without the disease. Furthermore, there were no differences between the study population and the controls. It is concluded that there is not necessarily a HLA–associated susceptibility in oral submucous fibrosis. Copyright © 1994, Wiley Blackwell. All rights reserved
Authors & Co-Authors
van Wyk, Christian Werner
South Africa, Stellenbosch
Stellenbosch University
Grobler‐Rabie, Anne F.
South Africa, Stellenbosch
Stellenbosch University
Martell, Robert W.
South Africa, Cape Town
Cape Provincial Administration
Hammond, Michael G.
South Africa, Pinetown
Natal Institute of Immunology
Statistics
Citations: 37
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1111/j.1600-0714.1994.tb00249.x
ISSN:
09042512
e-ISSN:
16000714
Research Areas
Health System And Policy
Study Design
Cross Sectional Study
Study Locations
South Africa