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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Biological differences between the sexes and susceptibility to tuberculosis
Journal of Infectious Diseases, Volume 209, No. SUPPL. 3, Year 2014
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Description
Globally, far more men than women have tuberculosis. Although the cause of this bias is uncertain, epidemiological factors have historically been considered the driving force. Here, we discuss evidence that biological differences between the sexes may also be important and can affect susceptibility to mycobacterial infection. We discuss the possible underlying mechanisms, with particular focus on how sex hormones modulate the immune responses necessary for resistance to tuberculosis. Studying these differences may provide valuable insight into the components that constitute an effective immune response to this deadly pathogen. © 2014 The Author.
Authors & Co-Authors
Nhamoyebonde, Shepherd
South Africa, Durban
The Nelson R. Mandela Medical School
Leslie, Alasdair J.
South Africa, Durban
The Nelson R. Mandela Medical School
Statistics
Citations: 214
Authors: 2
Affiliations: 1
Identifiers
Doi:
10.1093/infdis/jiu147
ISSN:
00221899
e-ISSN:
15376613
Participants Gender
Male
Female