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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Polychromatic immunophenotypic characterization of T cell profiles among HIV-infected patients experiencing immune reconstitution inflammatory syndrome (IRIS)
AIDS Research and Therapy, Volume 6, Article 6, Year 2009
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Description
Objective: To immunophenotype CD4+ and CD8+ T cell sub-populations in HIV-associated immune reconstitution inflammatory syndrome (IRIS). Design: Nested case-control immunological study. Methods: ART-naïve HIV-infected patients were prospectively observed for IRIS during the first 6 months of ART. Twenty-two IRIS cases and 22 ART-duration matched controls were sampled for T cell immunophenotyping. Results: IRIS cases demonstrated significantly lower CD4 cell counts compared to controls (baseline: 79 versus 142, p = 0.02; enrollment: 183 versus 263, p = 0.05, respectively) with no differences in HIV RNA levels. Within CD4+T cells, cases exhibited more of an effector memory phenotype compared to controls (40.8 versus 27.0%, p = 0.20), while controls trended towards a central memory phenotype (43.8 versus 30.8%, p = 0.07). Within CD8+ T cells, controls exhibited more central memory (13.9 versus 7.81%, p = 0.01, respectively) and effector (13.2 versus 8.8%, p = 0.04, respectively) phenotypes compared to cases, whereas cases demonstrated more terminal effectors than controls (28.8 versus 15.1%, p = 0.05). Cases demonstrated increased activation of CD8+ T cell effector memory, terminal effector, and effector subsets than controls (p = 0.04, 0.02, and 0.02, respectively). Conclusion: CD4+ and CD8+ T cell subset maturational phenotypes were heterogeneous among IRIS cases and controls. However, IRIS cases demonstrated significant increases in activation of CD8+ T cell effector subpopulations. © 2009 Murdoch et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Murdoch, David M.
United States, Durham
Duke University Medical Center
Suchard, Melinda Shelley
South Africa, Johannesburg
University of the Witwatersrand
Venter, Willem Daniel François
South Africa, Johannesburg
University of the Witwatersrand
Mhlangu, Patrick
South Africa, Johannesburg
Contract Laboratory Services
Ottinger, Janet S.
United States, Durham
Duke University
Feldman, Charles
South Africa, Johannesburg
University of the Witwatersrand
van Rie, Annelies
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Glencross, Deborah Kim
South Africa, Johannesburg
University of the Witwatersrand
South Africa, Johannesburg
Contract Laboratory Services
Stevens, Wendy Susan
South Africa, Johannesburg
University of the Witwatersrand
Weinhold, Kent J.
United States, Durham
Duke University
Statistics
Citations: 13
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1186/1742-6405-6-6
ISSN:
17426405
Research Areas
Infectious Diseases
Study Design
Case-Control Study