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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genome-wide association study in a Lebanese cohort confirms PHACTR1 as a major determinant of coronary artery stenosis
PLoS ONE, Volume 7, No. 6, Article e38663, Year 2012
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Description
The manifestation of coronary artery disease (CAD) follows a well-choreographed series of events that includes damage of arterial endothelial cells and deposition of lipids in the sub-endothelial layers. Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are a crucial step in understanding global CAD pathophysiology. In this study, we report a GWAS on the genetic basis of arterial stenosis as measured by cardiac catheterization in a Lebanese population. The locus of the phosphatase and actin regulator 1 gene (PHACTR1) showed association with coronary stenosis in a discovery experiment with genome wide data in 1,949 individuals (rs9349379, OR = 1.37, p = 1.57×10 -5). The association was replicated in an additional 2,547 individuals (OR = 1.31, p = 8.85×10 -6), leading to genome-wide significant association in a combined analysis (OR = 1.34, p = 8.02×10 -10). Results from this GWAS support a central role of PHACTR1 in CAD susceptibility irrespective of lifestyle and ethnic divergences. This association provides a plausible component for understanding molecular mechanisms involved in the formation of stenosis in cardiac vessels and a potential drug target against CAD. © 2012 Hager et al.
Authors & Co-Authors
Hager, Jörg
France, Evry
Centre National de Recherche en Génomique Humaine
Kamatani, Yoichiro
France, Paris
Fondation Jean Dausset - Ceph
Cazier, Jean Baptiste
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Youhanna, Sonia C.
Lebanon, Beirut
Lebanese American University
Ghassibe-Sabbagh, Michella
Lebanon, Beirut
Lebanese American University
Platt, Daniel E.
United States, Yorktown Heights
Ibm Thomas J. Watson Research Center
AbchÉE, Antoine B.
Lebanon, Beirut
American University of Beirut
Romanos, Jihane
Lebanon, Beirut
Lebanese American University
Khazen, Georges
Lebanon, Beirut
Lebanese American University
Othman, Raed
Lebanon, Beirut
Rafik Hariri University Hospital
BADRO, Danielle A.
Lebanon, Beirut
Lebanese American University
Haber, Marc E.
Lebanon, Beirut
Lebanese American University
Salloum, Angélique K.
Lebanon, Beirut
Lebanese American University
Douaihy, Bouchra
Lebanon, Beirut
Lebanese American University
Shasha, Nabil
Lebanon, Beirut
Rafik Hariri University Hospital
Kabbani, Samer
Lebanon, Beirut
Rafik Hariri University Hospital
Sbeite, Hana
Lebanon, Beirut
Lebanese American University
Chammas, Elie J.
Lebanon, Beirut
Lebanese American University
el Bayeh, Hamid
Lebanon, Beirut
Lebanese American University
Rousseau, Francis
France, Evry
Genopole
Zélénika, Diana
France, Evry
Centre National de Recherche en Génomique Humaine
Gut, I. Glynne
France, Evry
Centre National de Recherche en Génomique Humaine
Lathrop, Mark G.
France, Evry
Centre National de Recherche en Génomique Humaine
Farrall, Martin
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Gauguier, Dominique
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
France, Paris
Centre de Recherche Des Cordeliers
Zalloua, Pierre A.
Lebanon, Beirut
Lebanese American University
United States, Boston
Harvard T.h. Chan School of Public Health
Statistics
Citations: 26
Authors: 26
Affiliations: 10
Identifiers
Doi:
10.1371/journal.pone.0038663
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative