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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Federated learning enables big data for rare cancer boundary detection
Nature Communications, Volume 13, No. 1, Article 7346, Year 2022
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Description
Although machine learning (ML) has shown promise across disciplines, out-of-sample generalizability is concerning. This is currently addressed by sharing multi-site data, but such centralization is challenging/infeasible to scale due to various limitations. Federated ML (FL) provides an alternative paradigm for accurate and generalizable ML, by only sharing numerical model updates. Here we present the largest FL study to-date, involving data from 71 sites across 6 continents, to generate an automatic tumor boundary detector for the rare disease of glioblastoma, reporting the largest such dataset in the literature (n = 6, 314). We demonstrate a 33% delineation improvement for the surgically targetable tumor, and 23% for the complete tumor extent, over a publicly trained model. We anticipate our study to: 1) enable more healthcare studies informed by large diverse data, ensuring meaningful results for rare diseases and underrepresented populations, 2) facilitate further analyses for glioblastoma by releasing our consensus model, and 3) demonstrate the FL effectiveness at such scale and task-complexity as a paradigm shift for multi-site collaborations, alleviating the need for data-sharing. © 2022, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC9722782/bin/41467_2022_33407_MOESM1_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC9722782/bin/41467_2022_33407_MOESM2_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC9722782/bin/41467_2022_33407_MOESM3_ESM.pdf
Authors & Co-Authors
Baid, Ujjwal R.
United States, Philadelphia
University of Pennsylvania
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Davatzikos, Christos A.
United States, Philadelphia
University of Pennsylvania
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Bilello, Michel
United States, Philadelphia
University of Pennsylvania
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Sahm, Felix
Germany, Heidelberg
German Cancer Research Center
Germany, Heidelberg
Universitätsklinikum Heidelberg
Maier-Hein, Klaus Hermann Fritzsche)
Germany, Heidelberg
German Cancer Research Center
Germany, Heidelberg
Universitätsklinikum Heidelberg
Bendszus, Martin
Germany, Heidelberg
Universitätsklinikum Heidelberg
Villanueva-Meyer, Javier E.
United States, San Francisco
University of California, San Francisco
Jeraj, Robert
United States, Madison
University of Wisconsin-madison
Palmer, Joshua D.
United States, Columbus
The Ohio State University Comprehensive Cancer Center
Jones, Craig K.
United States, Baltimore
Johns Hopkins University
Ellingson, Benjamin M.
United States, Los Angeles
University of California, Los Angeles
Raymond, Catalina
United States, Los Angeles
University of California, Los Angeles
Falcão, Alexandre Xavier
Brazil, Campinas
Universidade Estadual de Campinas
Slotboom, Johannes
Switzerland, Bern
University of Bern
Wiest, Roland G.
Switzerland, Bern
University of Bern
Ormond, David Ryan
United States, Aurora
University of Colorado Anschutz Medical Campus
Colen, Rivka R.
United States, Pittsburgh
University of Pittsburgh
United States, Houston
The University of Texas Md Anderson Cancer Center
Srinivasan, Ashok A.
United States, Ann Arbor
University of Michigan, Ann Arbor
Rao, Arvind U.K.
United States, Ann Arbor
University of Michigan, Ann Arbor
Moritani, Toshio
United States, Ann Arbor
University of Michigan, Ann Arbor
Türk, Sevcan
United States, Ann Arbor
University of Michigan, Ann Arbor
Morón, Fanny E.
United States, Houston
Baylor College of Medicine
Dixon, Luke V.M.
United Kingdom, London
Imperial College Healthcare Nhs Trust
Kalogeropoulou, Christina P.
Greece, Rio
University of Patras
Kardamakis, D.
Greece, Rio
University of Patras
Wen, Ning (Winston)
United States, Detroit
Henry Ford Health System
China, Shanghai
Shanghai Jiao Tong University
Verma, Ruchika
United States, Cleveland
Case Western Reserve University
Bareja, Rohan
United States, Cleveland
Case Western Reserve University
Fortin, David D.
Canada, Sherbrooke
Université de Sherbrooke
Gusev, Yuriy
United States, Washington, D.c.
Georgetown University
Modat, Marc
United Kingdom, London
King's College London
Shuaib, Haris
United Kingdom, Aylesbury
Stoke Mandeville Hospital
Canada, Kingston
Queen’s University
Abayazeed, Aly H.
United States, Groton
Neosoma Inc.
Hill, Michael
United States, Groton
Neosoma Inc.
Abbassy, Ahmed
Egypt, Giza
Cairo University
Gamal, Shady Mohamed Tarek
Egypt, Giza
Cairo University
Mekhaimar, Mahmoud Ibrahim
Egypt, Giza
Cairo University
Qayati, Mohamed
Egypt, Giza
Cairo University
Reyes, Mauricio
Switzerland, Bern
University of Bern
Beets-Tan, Regina G.H.
Netherlands, Amsterdam
The Netherlands Cancer Institute
Netherlands, Maastricht
Faculty of Health, Medicine and Life Sciences
Kotrotsou, Aikaterini
United States, Houston
University of Texas Health Science Center at Houston
Li, Hongwei
Switzerland, Zurich
Universität Zürich
Saltz, Joel Haskin
United States, Stony Brook
Stony Brook University
Velastín, Sergio A.
United Kingdom, London
Queen Mary University of London
Ogbole, G. I.
Nigeria, Ibadan
University College Hospital, Ibadan
Soneye, Mayowa
Nigeria, Ibadan
University College Hospital, Ibadan
Oyekunle, Dotun
Nigeria, Ibadan
University College Hospital, Ibadan
Osobu, Babatunde Ebenezer
Nigeria, Ibadan
University College Hospital, Ibadan
Dako, Farouk
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
United States, Philadelphia
University of Pennsylvania
Menze, Bjoern H.
Germany, Munich
Technische Universität München
Switzerland, Zurich
Universität Zürich
Barnholtz-Sloan, Jill S.
United States, Bethesda
National Institutes of Health Nih
Statistics
Citations: 40
Authors: 51
Affiliations: 94
Identifiers
Doi:
10.1038/s41467-022-33407-5
ISSN:
20411723
Research Areas
Cancer
Health System And Policy