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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Insecticide resistance in the malarial mosquito Anopheles arabiensis and association with the kdr mutation
Medical and Veterinary Entomology, Volume 21, No. 1, Year 2007
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Description
A colony of Anopheles arabiensis Patton (Diptera: Culicidae) from the Sennar region of Sudan was selected for resistance to dichlorodiphenyltrichloroethane (DDT). Adults from the F-16 generation of the resistant strain were exposed to all four classes of insecticides approved for use in malaria vector control and showed high levels of resistance to them all (24-h mortalities: malathion, 16.7%; bendiocarb, 33.3%; DDT, 12.1%; dieldrin, 0%; deltamethrin, 24.0%; permethrin, 0%). Comparisons between the unselected base colony and the DDT-resistant strain showed elevated glutathione-S- transferase (P < 0.05) in both sexes and elevated esterases (P < 0.05) in males only. The Leu-Phe mutation in the sodium channel gene was detected by polymerase chain reaction and sequencing, but showed no correlation with the resistant phenotype. These results do not provide any explanation as to why this colony exhibits such widespread resistance and further studies are needed to determine the precise mechanisms involved. The implications for malaria vector control in central Sudan are serious and resistance management (e.g. through the rotational use of different classes of insecticides) is recommended. © 2007 The Authors.
Authors & Co-Authors
Matambo, Tonderayi S.
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Johannesburg
University of the Witwatersrand
Abdalla, Hiba
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Johannesburg
University of the Witwatersrand
Sudan
Blue Nile Research and Training Institute
Brooke, Basil D.
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Johannesburg
School of Pathology
Koekemoer, Lizette Leonie
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Johannesburg
School of Pathology
Mnzava, Abraham Peter
Switzerland, Geneva
Organisation Mondiale de la Santé
Hunt, Richard H.
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Johannesburg
University of the Witwatersrand
Coetzee, Maureen
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Johannesburg
School of Pathology
South Africa, Sandringham
Nicd
Statistics
Citations: 7
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1111/j.1365-2915.2007.00671.x
ISSN:
0269283X
e-ISSN:
13652915
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Locations
Sudan