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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The Mediterranean basin: A population genetic study based on 25 X-chromosome SNPs
Forensic Science International: Genetics Supplement Series, Volume 1, No. 1, Year 2008
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Description
The X-chromosome has valuable characteristics for population genetic studies. In order to investigate the genetics of the human Mediterranean populations further, we developed a 25 X-chromosome SNP-multiplex typing system. The system was based on PCR multiplex amplification and subsequent multiplex single base extension with the SNaPshot reaction, capillary electrophoresis and multicolor fluorescence detection. We investigated 11 Mediterranean populations with the 25 X-chromosome SNPs. A high overall homogeneity was found among the Mediterranean populations except for Moroccans, who differed genetically from the rest of the populations in the Mediterranean area. This result supports the hypothesis of a low incidence of the south-north genetic interchange at the western shores of the Mediterranean basin. A low genetic distance was found between populations in the Middle East and the western part of the Mediterranean area most likely reflecting the strong effect of the Neolithic wave. A certain level of background linkage disequilibrium among the 25 SNPs on the X-chromosome in Ibiza and Cosenza was observed, possibly as a consequence of their demographic history. © 2008 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Tomás, Carmen
Denmark, Copenhagen
Det Sundhedsvidenskabelige Fakultet
Spain, Palma
Universitat de Les Illes Balears
Sànchez, Juan J.
Denmark, Copenhagen
Det Sundhedsvidenskabelige Fakultet
Spain, Madrid
Instituto Nacional de Toxicologia y Ciencias Forenses
Barbaro, Anna M.
Italy, Reggio Calabria
Sezione Di Genetica Forense
Brandt-Casadevall, Conxita
Switzerland, Lausanne
Universitaires de Médecine Légale
Hernández, Alexis M.
Spain, Madrid
Instituto Nacional de Toxicologia y Ciencias Forenses
Ben Dhiab, Mohamed Mounir
Tunisia, Sousse
Hopital Farhat Hached Sousse
Ramón, Misericòrdia Misericor̀dia
Spain, Palma
Universitat de Les Illes Balears
Morling, Niels
Denmark, Copenhagen
Det Sundhedsvidenskabelige Fakultet
Statistics
Citations: 8
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1016/j.fsigss.2007.08.014
ISSN:
18751768
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Cohort Study