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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
dentistry
Effect of topical application of doxycycline on pulp revascularization and periodontal healing in reimplanted monkey incisors
Dental Traumatology, Volume 6, No. 4, Year 1990
Notification
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Description
Abstract Maxillary incisors in 47 monkeys, 54 in the experimental group (I) and 117 in the control group (II), were extracted and reimplanted, either immediately or after 30 or 60 min wet or dry storage. Incisors in the experimental group I were additionally kept 5 min in a suspension of 1 mg doxycycline in 20 ml physiologic saline, freshly prepared for each of the 15 animals before reimplantation. The observation time varied from 6 to 8 weeks. The teeth were removed in tissue blocks, histologically processed and evaluated for occurrence of complete pulp revascularization (CPR), presence of the micro‐organisms in the pulpal lumen and ankylosis or inflammatory root resorption. Then the results were statistically evaluated, using log‐linear analyses and chi‐square tests (SAS, 1985) for the comparisons between group I and group II. These analyses revealed that topical application of doxycycline increased the frequency of complete pulp revascularization (P < 0.002) and decreased the frequency of micro‐organisms in the pulpal lumen (P < 0.001). Furthermore, the frequencies of ankylosis (P < 0.05) and inflammatory root resorption (P < 0.001) were also decreased compared with the control group of teeth. It was concluded that the effect of topical treatment with doxycycline was most probably exerted on the micro‐organisms that contaminated root surface during the extra‐alveolar time; contamination of necrotic pulp tissue from the mechanical damage in the cervical part of the root surface was not affected. Copyright © 1990, Wiley Blackwell. All rights reserved
Authors & Co-Authors
Cvek, Miomir
Sweden, Stockholm
Eastman Dental Institute, Stockholm
Cleaton-Jones, P.
South Africa, Johannesburg
University of the Witwatersrand
Austin, John C.
South Africa, Tygerberg
South African Medical Research Council
Lownie, John Forsyth
Oral
Division of Maxillo-facial
Kling, Margareta
Sweden, Stockholm
Eastman Dental Institute, Stockholm
Fatti, Libero Paul
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 199
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1111/j.1600-9657.1990.tb00413.x
ISSN:
16004469
e-ISSN:
16009657
Study Design
Randomised Control Trial