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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Beilschglabrines A and B: Two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra
Phytochemistry Letters, Volume 16, Year 2016
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Description
Two new phenanthrene alkaloids, beilschglabrines A (1) and B (2) were isolated from the stem bark of Beilschmiedia glabra, together with lupeol, taraxerol, and 24-methylenelanosta-7,9-diene-3β-15α-diol. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis and comparison with respective literature data. The compounds were tested for DPPH radical scavenging, acetylcholinesterase and lipoxygenase inhibitory activities. Compound 1 displayed considerable activity in the acetylcholinesterase (IC50 50.4 μM), the DPPH radical scavenging (IC50 115.9 μM) and the lipoxygenase (IC50 32.8 μM) assays. © 2016 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Authors & Co-Authors
Salleh, Wan Mohd Nuzul Hakimi Wan
Malaysia, Johor Bahru
Universiti Teknologi Malaysia
Ahmad, Farediah
Malaysia, Johor Bahru
Universiti Teknologi Malaysia
Khong, Heng Yen
Malaysia, Shah Alam
Universiti Teknologi Mara
Nahar, Lutfun
United Kingdom, Liverpool
Liverpool John Moores University
Wansi, Jean Duplex
United Kingdom, Liverpool
Liverpool John Moores University
Sarker, Satyajit Dey
United Kingdom, Liverpool
Liverpool John Moores University
Statistics
Citations: 18
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/j.phytol.2016.04.013
ISSN:
18743900