Publication Details

AFRICAN RESEARCH NEXUS

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medicine

In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid

Antimicrobial Agents and Chemotherapy, Volume 53, No. 7, Year 2009

We tested the effect of probenecid and verapamil in chemosensitizing Plasmodium falciparum to 14 antimalarials using the multidrug-resistant strain V1S and the drug-sensitive 3D7. Verapamil chemosensitizes V1S to quinine and chloroquine. Interestingly, probenecid profoundly chemosensitizes V1S to piperaquine. Thus, probenecid could be used to increase piperaquine efficacy in vivo. Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Statistics
Citations: 19
Authors: 3
Affiliations: 2
Identifiers
Doi: 10.1128/AAC.01689-08
ISSN: 00664804
e-ISSN: 10986596

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