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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
In vitro activity of quinolines against Plasmodium falciparum in Gabon
Acta Tropica, Volume 90, No. 1, Year 2004
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Description
The assessment of drug sensitivity of Plasmodium falciparum to antimalarial drugs is of vital interest for malaria endemic regions. We conducted a follow-up study to monitor the in vitro activity of the most commonly used quinolines against fresh P. falciparum isolates in Lambaréné, Gabon by measuring schizont maturation inhibition in 2002. Mean 50% effective concentration levels for chloroquine, quinine, and mefloquine were 5.5μmol/l blood, 286nmol/l blood medium mixture (BMM), and 1.1μmol/l blood, respectively. All isolates (n=40) were found to be highly resistant to chloroquine. One isolate was resistant to mefloquine and five isolates were presenting borderline-resistance. All isolates were inhibited by quinine concentrations below the threshold of resistance (n=43). Besides the observation of an increasing number of borderline resistant isolates to mefloquine, an extremly high parasite resistance to chloroquine - still officially the first line antimalarial in Gabon - seems to be of particular concern. © 2003 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Ramharter, Michael
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Wernsdorfer, Walther Helmut
Austria, Vienna
Universität Wien
Kremsner, Peter G.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Statistics
Citations: 64
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1016/j.actatropica.2003.11.001
ISSN:
0001706X
Research Areas
Infectious Diseases
Study Design
Cohort Study
Study Locations
Gabon