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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Influence of HLA alleles on shedding of kaposi sarcoma-associated herpesvirus in saliva in an African population
Journal of Infectious Diseases, Volume 195, No. 6, Year 2007
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Description
Background. Kaposi sarcoma-associated herpesvirus (KSHV) is endemic in sub-Saharan Africa. Infection in childhood involves mother-to-child transmission and transmission between siblings or other close contacts. Large amounts of viral DNA in saliva have been linked to transmission from mother to child. To investigate factors contributing to the shedding of KSHV in the saliva of mothers in rural South Africa, we sequenced the HLA-A alleles of 448 mothers and the HLA-DRB1 alleles of 363 mothers and compared their HLA types with viral loads in saliva. Methods. Viral load was quantified with real-time polymerase chain reaction on DNA extracted from saliva. HLA-A and HLA-DRB1 allele groups were determined by sequencing-based typing. Results. We found that 2 HLA-A alleles, A*6801 and A*4301, and 1 HLA-DRB1 allele group, DRB1*04, were associated with shedding of KSHV in saliva. KSHV could be detected more frequently in mothers carrying at least 1 copy of HLA-A*6801 or HLA-A*4301, and higher viral loads were found in HLA-A*68- and HLA-DRB1*04-carrying mothers. Conclusions. These findings could suggest that 2 HLA-A alleles, A*6801 and A*4301, and 1 HLA-DRB1 allele group, DRB1*04, that are more frequent in African populations might be associated with an impaired control of KSHV and, hence, increased shedding in saliva. © 2007 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Alkharsah, Khaled R.
Germany, Hannover
Hannover Medical School
Dedicoat, Martin John
South Africa, Hlabisa
Hlabisa Hospital
Blasczyk, Rainer
Germany, Hannover
Hannover Medical School
Newton, Robert A.
United Kingdom, York
University of York
Schulz, Thomas Friedrich
Germany, Hannover
Hannover Medical School
Statistics
Citations: 44
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1086/511827
ISSN:
00221899
Research Areas
Cancer
Genetics And Genomics
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
South Africa