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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
High number of potential transmitters revealed in a population-based systematic hepatitis C Virus RNA screening among human immunodeficiency virus-infected men who have sex with men
Clinical Infectious Diseases, Volume 68, No. 4, Year 2019
Notification
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Description
Background. The proportion of undiagnosed hepatitis C virus (HCV) infections in high-risk populations, such as human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) is unclear. Identification of potential HCV transmitters is important to reach World Health Organization HCV elimination targets. Methods. Between October 2015 and May 2016, we performed a systematic HCV RNA-based screening among HIV-infected MSM participating in the Swiss HIV Cohort Study (SHCS). HCV antibodies were measured from all HCV RNA-positive samples. Results. Of 4257 MSM recorded in the SHCS database, we screened 3722 (87%) by HCV polymerase chain reaction, and 177 (4.8%) harbored a replicating HCV infection. We identified 24 individuals (14%) with incident HCV infection; one-third of them had a negative HCV antibody result at the time of HCV RNA positivity. In a multivariable model, elevated liver enzyme values (odds ratio, 14.52; 95% confidence interval, 9.92-21.26), unprotected sex with occasional partners (2.01; 1.36-2.98), intravenous drug use (7.13; 4.36-11.64), noninjectable drug use (1.94; 1.3-2.88), and previous syphilis diagnosis (2.56; 1.74-3.76) were associated with HCV RNA positivity. Conclusions. A systematic HCV RNA-based screening among HIV-infected MSM revealed a high number of potential transmitters. A substantial subpopulation of MSM had incident infection, one-third of whom had a negative HCV antibody test result at the time of the HCV RNA positivity. These data reveal that one-time RNA testing of a high-risk population for HCV RNA might identify more infected persons than routine testing for HCV antibodies and liver enzymes. Clinical Trials Registration. NCT02785666. © The Author(s) 2018.
Authors & Co-Authors
Braun, Dominique Laurent
Switzerland, Zurich
Universität Zürich
Kouyos, Roger D.
Switzerland, Zurich
Universität Zürich
Kusejko, Katharina
Switzerland, Zurich
Universität Zürich
Flepp, Markus J.
Unknown Affiliation
Stöckle, Marcel
Switzerland, Basel
Universitat Basel
Schmid, Patrick
Switzerland, St Gallen
Kantonsspital St.gallen
Delaloye, Julie F.
Switzerland, Lausanne
Université de Lausanne Unil
Rougemont, Mathieu
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Bernasconi, Enos
Switzerland, Bellinzona
Ente Ospedaliero Cantonale
Rauch, Andri
Switzerland, Bern
University of Bern
Günthard, Huldrych F.
Switzerland, Zurich
Universität Zürich
Böni, Jürg
Switzerland, Zurich
Universität Zürich
Fehr, Jan Sven
Switzerland, Zurich
Universität Zürich
Anagnostopoulos, Alexia
Unknown Affiliation
Battegay, Manuel
Unknown Affiliation
Bucher, Heíner C.C.
Unknown Affiliation
Calmy, Alexandra L.
Unknown Affiliation
Cavassini, Matthias
Unknown Affiliation
Ciuffi, Angela
Unknown Affiliation
Dollenmaier, Guenter
Unknown Affiliation
Egger, Matthias
Unknown Affiliation
Elzi, Luigia
Unknown Affiliation
Fellay, Jacques
Unknown Affiliation
Furrer, Hansjakob Jackob
Unknown Affiliation
Fux, Christoph Andreas
Unknown Affiliation
Haerry, David Hans Ulrich
Unknown Affiliation
Hasse, Barbara Katharina
Unknown Affiliation
Hirsch, Hans H.
Unknown Affiliation
Hoffmann, Matthias
Unknown Affiliation
Hösli, Irene Mathilde
Unknown Affiliation
Huber, Michael J.
Unknown Affiliation
Kahlert, Christian R.
Unknown Affiliation
Kaiser, Laurent K.
Unknown Affiliation
Keiser, Olivia
Unknown Affiliation
Klimkait, Thomas
Unknown Affiliation
Kovari, Helen
Unknown Affiliation
Ledergerber, Bruno
Unknown Affiliation
Martinetti, Gladys
Unknown Affiliation
Martínez de Tejada, Begoῆa
Unknown Affiliation
Marzolini, Catia
Unknown Affiliation
Metzner, K. J.
Unknown Affiliation
Müller, Nicolas J.
Unknown Affiliation
Nicca, Dunja
Unknown Affiliation
Paioni, Paolo
Unknown Affiliation
Pantaleo, Giuseppe P.
Unknown Affiliation
Perreau, Matthieu
Unknown Affiliation
Rudin, Christoph
Unknown Affiliation
Scherrer, Alexandra U.
Unknown Affiliation
Speck, Roberto F.
Unknown Affiliation
Tarr, Philip E.
Unknown Affiliation
Trkola, Alexandra
Unknown Affiliation
Vernazza, Pietro Luigi
Unknown Affiliation
Wandeler, Gilles
Unknown Affiliation
Weber, Rainer
Unknown Affiliation
Yerly, Sabine T.B.D.
Unknown Affiliation
Statistics
Citations: 16
Authors: 55
Affiliations: 8
Identifiers
ISSN:
10584838
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Study Approach
Quantitative
Participants Gender
Male