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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The association of pattern of lifetime alcohol use and cause of death in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
International Journal of Epidemiology, Volume 42, No. 6, Article dyt154, Year 2013
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Description
Background There is limited evidence for an association between the pattern of lifetime alcohol use and cause-specific risk of death.Methods Multivariable hazard ratios were estimated for different causes of death according to patterns of lifetime alcohol consumption using a competing risks approach: 111 953 men and 268 442 women from eight countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study were included. Self-reported alcohol consumption at ages 20, 30, 40 or 50 years and at enrolment were used for the analysis; 26 411 deaths were observed during an average of 12.6 years of follow-up.Results The association between lifetime alcohol use and death from cardiovascular diseases was different from the association seen for alcohol-related cancers, digestive, respiratory, external and other causes. Heavy users (>5 drinks/day for men and >2.5 drinks/day for women), regardless of time of cessation, had a 2- to 5-times higher risk of dying due to alcohol-related cancers, compared with subjects with lifetime light use (≤1 and ≤0.5 drink/week for men and women, respectively). Compared with lifetime light users, men who used <5 drinks/day throughout their lifetime had a 24% lower cardiovascular disease mortality (95% confidence interval 2-41). The risk of death from coronary heart disease was also found to be 34-46% lower among women who were moderate to occasionally heavy alcohol users compared with light users. However, this relationship was only evident among men and women who had no chronic disease at enrolment.Conclusions Limiting alcohol use throughout life is associated with a lower risk of death, largely due to cardiovascular disease but also other causes. However, the potential health benefits of alcohol use are difficult to establish due to the possibility of selection bias and competing risks related to diseases occurring later in life. Published by Oxford University Press on behalf of the International Epidemiological Association. © The Author 2013; all rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3887563/bin/supp_42_6_1772__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3887563/bin/supp_dyt154_ije-2012-06-0527-File003.docx
Authors & Co-Authors
Bergmann, Manuela M.
Germany, Nuthetal
German Institute of Human Nutrition
Rehm, Jurgen T.
Canada, Toronto
Centre for Addiction and Mental Health
Germany, Dresden
Technische Universität Dresden
Klipstein-Grobusch, Kerstin
Netherlands, Utrecht
University Medical Center Utrecht
South Africa, Johannesburg
Wits School of Public Health
Boeing, Heiner
Germany, Nuthetal
German Institute of Human Nutrition
Schütze, Madlen
Germany, Nuthetal
German Institute of Human Nutrition
Drogan, Dagmar
Germany, Nuthetal
German Institute of Human Nutrition
Overvad, Kim
Denmark, Aarhus
Aarhus Universitet
Tjønneland, A. Marie
Denmark, Copenhagen
Kræftens Bekæmpelse
Halkjaer, Jytte
Denmark, Copenhagen
Kræftens Bekæmpelse
Fagherazzi, Guy
France, Villejuif
Centre de Recherche en Épidémiologie et Santé Des Populations
Boutron-Ruault, Marie Christine
France, Villejuif
Centre de Recherche en Épidémiologie et Santé Des Populations
Clavel-Chapelon, Fraņcoise
France, Villejuif
Centre de Recherche en Épidémiologie et Santé Des Populations
Teucher, Birgit
Germany, Heidelberg
German Cancer Research Center
Kaaks, Rudolf J.
Germany, Heidelberg
German Cancer Research Center
Trichopoulou, Antonia D.
Greece, Athens
School of Medicine
Greece, Athens
Hellenic Health Foundation, Athens
Benetou, Vassiliki
Greece, Athens
School of Medicine
Trichopoulos, Dimitrios V.
Greece, Athens
Hellenic Health Foundation, Athens
United States, Boston
Harvard T.h. Chan School of Public Health
Greece, Athens
Academy of Athens
Palli, Domenico
Italy
Centro Per lo Studio e la Prevenzione Oncologica
Pala, Valeria Maria
Italy, Milan
Fondazione Irccs Istituto Nazionale Dei Tumori, Milan
Tumino, Rosario
Italy, Ragusa
Azienda Ospedaliera Civile M.p. Arezzo
Vineis, Paolo
United Kingdom, London
Imperial College London
Italy, Torino
Hugef Foundation
Beulens, J. W.J.
Netherlands, Utrecht
University Medical Center Utrecht
Redondo, Maria Luisa
Spain, Oviedo
Public Health Directorate
Duell, Eric Jeffrey
Spain, Hospitalet de Llobregat
Institut D'investigació Biomedica de Bellvitge
Molina-Montes, Esther
Spain, Granada
Escuela Andaluza Salud Publica
Navarro, Carmen A.
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Barricarte, Aurelio
Spain, Pamplona
Consortium for Biomedical Research in Epidemiology and Public Health
Arriola, Larraitz
Spain, Donostia-san Sebastian
Biodonostia Health Research Institute
Allen, Naomi E.
United Kingdom, Oxford
University of Oxford
Crowe, Francesca
United Kingdom, Oxford
University of Oxford
Khaw, Kay Tee T.
United Kingdom, Cambridge
School of Clinical Medicine
Wareham, Nicholas J.
United Kingdom, Cambridge
Mrc Epidemiology Unit
Romaguera, D.
France, Lyon
Centre International de Recherche Sur le Cancer
Wark, Petra A.
United Kingdom, London
Imperial College London
Romieu, Isabelle
United Kingdom, London
Imperial College London
Nunes, Luciana Neves
Brazil, Porto Alegre
Universidade Federal do Rio Grande do Sul
Riboli, Elio B.
France, Lyon
Centre International de Recherche Sur le Cancer
Ferrari, Pietro
United Kingdom, London
Imperial College London
Statistics
Citations: 131
Authors: 38
Affiliations: 29
Identifiers
Doi:
10.1093/ije/dyt154
ISSN:
03005771
e-ISSN:
14643685
Research Areas
Cancer
Environmental
Food Security
Noncommunicable Diseases
Substance Abuse
Study Design
Cohort Study
Participants Gender
Male
Female