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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Role of gender and estrogen receptors in the rat aorta endothelium-dependent relaxation to red wine polyphenols
Vascular Pharmacology, Volume 51, No. 2-3, Year 2009
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Description
Regular intake of moderate amounts of beverages rich in polyphenols such as red wine is associated with a protective effect on the vascular system, in part, by increasing the endothelial formation of nitric oxide (NO), a major vasoprotective factor. Since estrogens are potent inducers of NO formation and polyphenols have been shown to have phytoestrogen properties, we determined whether estrogen receptors mediate the stimulatory effect of red wine polyphenols (RWPs) on the endothelial formation of NO using isolated rat aortic rings and cultured endothelial cells. RWPs caused endothelium-dependent relaxations, which were more pronounced in the aorta of female than male rats. Increased relaxations were also observed to acetylcholine but not to sodium nitroprusside. Relaxations to RWPs were abolished by nitro l-arginine and MnTMPyP, markedly reduced by polyethyleneglycol-catalase and wortmannin, and not affected by the estrogen antagonist ICI 182,780 in aortic rings from males and females. eNOS expression was higher in aortic sections of female than male rats. RWPs caused the phosphorylation of Akt and eNOS in endothelial cells, which was unaffected by ICI 182,780. Thus, RWPs cause redox-sensitive PI3-kinase/Akt-dependent NO-mediated relaxations, which are more pronounced in the aorta of female than male rats; an effect most likely due to the increased expression level of eNOS rather than activation of estrogen receptors. © 2009 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Kane, Modou Oumy
France, Paris
Cnrs Centre National de la Recherche Scientifique
Senegal, Dakar
Universite Cheikh Anta Diop Faculte de Medecine et de Pharmacie
Anselm, Eric
France, Paris
Cnrs Centre National de la Recherche Scientifique
Rattmann, Yanna Dantas
France, Paris
Cnrs Centre National de la Recherche Scientifique
Auger, Cyril
France, Paris
Cnrs Centre National de la Recherche Scientifique
Schini-Kerth, Valérie Barbara
France, Paris
Cnrs Centre National de la Recherche Scientifique
Statistics
Citations: 38
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/j.vph.2009.05.002
ISSN:
15371891
Participants Gender
Male
Female