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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Intermittent preventive treatment using artemisinin-based combination therapy reduces malaria morbidity among school-aged children in Mali
Tropical Medicine and International Health, Volume 14, No. 7, Year 2009
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Description
Objective To assess the efficacy of intermittent preventive treatment (IPT) against malaria in school-aged children. Methods This was an open randomized controlled trial of seasonal IPT among school children (IPTsc) aged 6-13 years in Kollé, Mali. The study began in September 2007 and completed follow-up in May 2008. Students were randomized to one of three study arms: Sulfadoxine-pyrimethamine plus artesunate (SP/AS), amodiaquine plus artesunate (AQ/AS) or vitamin C. All students received two full treatment doses, given 2 months apart during the season of high transmission from September to December. Groups were compared with respect to incidence of clinical malaria, asymptomatic parasitemia and haemoglobin concentration. Results A total of 296 students were randomized, and retention in the study was 99.3%. Clinical malaria incidence in the SP/AS and AQ/AS arms was reduced by 66.6% and 46.5%, respectively, vs. vitamin C (P < 0.001). There were fewer clinic visits for any cause among the children receiving SP/AS or AQ/AS (P = 0.024). The prevalence of asymptomatic parasitemia was fivefold higher in the vitamin C arm than either SP/AS or AQ/AS at each post-treatment evaluation (P < 0.001). At the end of the transmission period, children treated with IPT had lower rates of anaemia (SP/AS, 17.7%; AQ/AS, 16.0%; vitamin C, 29.6%; P = 0.039). Conclusion IPT among school children reduced the rates of clinical malaria, all-cause acute clinic visits, asymptomatic parasitemia and anaemia among school-aged children. © 2009 Blackwell Publishing Ltd.
Authors & Co-Authors
Barger, Breanna
United States, Seattle
University of Washington School of Medicine
Maïga, Hamidou
Mali, Bamako
University of Bamako
Traoré, Oumar Bila
Mali, Bamako
University of Bamako
Tékété, Mamadou M.
Mali, Bamako
University of Bamako
Tembine, Intimbeye
Mali, Bamako
University of Bamako
Dara, Antoine
Mali, Bamako
University of Bamako
Traoré, Zoumana Isaac
Mali, Bamako
University of Bamako
Gantt, Soren M.
United States, Seattle
University of Washington
Doumbo, Ogobara K.
Mali, Bamako
University of Bamako
Djimde, Abdoulaye A.
Mali, Bamako
University of Bamako
Statistics
Citations: 45
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1111/j.1365-3156.2009.02294.x
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Mali