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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Higher Isolation of NDM-1 Producing Acinetobacter baumannii from the Sewage of the Hospitals in Beijing
PLoS ONE, Volume 8, No. 6, Article e64857, Year 2013
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Description
Multidrug resistant microbes present in the environment are a potential public health risk. In this study, we investigate the presence of New Delhi metallo-β-lactamase 1 (NDM-1) producing bacteria in the 99 water samples in Beijing City, including river water, treated drinking water, raw water samples from the pools and sewage from 4 comprehensive hospitals. For the blaNDM-1 positive isolate, antimicrobial susceptibility testing was further analyzed, and Pulsed Field Gel Electrophoresis (PFGE) was performed to determine the genetic relationship among the NDM-1 producing isolates from sewage and human, as well as the clinical strains without NDM-1. The results indicate that there was a higher isolation of NDM-1 producing Acinetobacter baumannii from the sewage of the hospitals, while no NDM-1 producing isolates were recovered from samples obtained from the river, drinking, or fishpond water. Surprisingly, these isolates were markedly different from the clinical isolates in drug resistance and pulsed field gel electrophoresis profiles, suggesting different evolutionary relationships. Our results showed that the hospital sewage may be one of the diffusion reservoirs of NDM-1 producing bacteria. © 2013 Zhang et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3670931/bin/pone.0064857.s001.tif
Authors & Co-Authors
Li, Zhenjun
Unknown Affiliation
Huang, Liuyu
China, Beijing
Academy of Military Sciences
Klena, John David
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 110
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1371/journal.pone.0064857
ISSN:
19326203
Research Areas
Environmental
Genetics And Genomics
Health System And Policy