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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Biological sex influences antibody responses to routine vaccinations in the first year of life
Acta Paediatrica, International Journal of Paediatrics, Volume 109, No. 1, Year 2020
Notification
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Description
Aim: We investigated the effect of early-life factors, namely sex, delivery mode, feeding method and antibiotic exposure, on antibody responses to routine vaccinations administered during the first year of life. Methods: One and seven months after the primary course of routine vaccines and 1 month after routine vaccines at 12 months of age, antibodies against 26 vaccine antigens were measured in 398 healthy infants. The geometric mean concentration (GMC) of antibodies (adjusted for effect modifiers with multiple linear regression) and the seroprotection rate for each vaccine were compared for each early-life factor. Results: Sex had an influence on GMCs. Antibody concentrations were significantly lower at 7 months of age in females for tetanus and filamentous haemagglutinin and at 13 months of age for pertactin. In contrast, at 13 months of age, antibody concentrations were significantly higher in females for polio type 3, pneumococcal serotype 6A and measles. Sex did not have an influence on seroprotection rates. Delivery mode, feeding method and antibiotic exposure did not exert a substantial influence on vaccine antibody concentrations. Conclusion: There is a difference between males and females in the humoral response to routine vaccinations in the first year of life. © 2019 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd
Authors & Co-Authors
Perrett, Kirsten P.
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
Royal Children's Hospital, Melbourne
Australia, Melbourne
University of Melbourne
Ritz, Nicole
Australia, Melbourne
University of Melbourne
Switzerland, Basel
Universitäts-kinderspital Beider Basel
Flanagan, Katie L.
Australia, Clayton
Monash University
Robins-Browne, Roy Michael
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
University of Melbourne
van der Klis, Fiona Regina Maria
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Curtis, Nigel C.
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
Royal Children's Hospital, Melbourne
Abruzzo, Veronica
Unknown Affiliation
Bonnici, Rhian
Unknown Affiliation
Casalaz, Dan M.
Unknown Affiliation
Freyne, Bridget Joan
Unknown Affiliation
Gardiner, Kaya Kareela
Unknown Affiliation
Germano, Susie
Unknown Affiliation
Kollmann, Tobias R.
Unknown Affiliation
Messina, Nicole L.
Unknown Affiliation
Morrison, Clare
Unknown Affiliation
Nakaya, Helder
Unknown Affiliation
Ponsonby, Anne Louise
Unknown Affiliation
Shann, Frank A.
Unknown Affiliation
Vuillermin, Peter J.
Unknown Affiliation
Statistics
Citations: 7
Authors: 19
Affiliations: 7
Identifiers
Doi:
10.1111/apa.14932
ISSN:
08035253
Research Areas
Infectious Diseases
Participants Gender
Female