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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Breastfeeding, HIV status and weights in South African children: A comparison of HIV-exposed and unexposed children
AIDS, Volume 24, No. 3, Year 2010
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Description
Objectives: To examine growth of children by maternal and infant HIV status allowing for infant feeding mode. Design: Women enrolled into a nonrandomized intervention cohort. Methods: Children of HIV-infected and uninfected women weighed and assessed for HIV status, monthly: from birth to 9 months; quarterly: 10-24 months. Daily infant feeding practices recorded at weekly intervals. Weight-for-age z-scores of children born to HIV-infected mothers compared with the reference population of children of HIV-uninfected mothers. Changes in z-scores over age were examined by HIV infection status and infant feeding practice using linear mixed effects models. Results: The 1261 children of HIV-infected mothers grew as well as the reference group of 1061 children of HIV-uninfected mothers, irrespective of feeding mode. z-scores for HIV-infected children were consistently lower than those of HIV-exposed but uninfected children: a difference of 420 g for male children and 405 g for female children at 52 weeks of age. Breastfed HIV-infected infants had consistently higher z-scores for weight, especially during first 6 weeks (difference of 130 g for male children; 110 g for female children). In an adjusted regression analysis, maternal mid-upper arm circumference, CD4 cell count, infant birth weight and HIV status had the biggest impact on infant growth (z-score coefficient: 0.38 for mid-upper arm circumference ≥28.35 vs. <25.7 cm; P < 0.001;-0.32 for CD4 cell count <200 vs. ≥500; P = 0.001;-2.01 for birth weight <2500 vs. ≥2500 g; P < 0.001;-0.20 for infected vs. uninfected children; P < 0.001). Conclusion: Optimal early feeding practices ameliorate the effect of being born to an HIV-infected mother and strengthen the recommendation of exclusive breastfeeding for HIV-infected women in terms of long-term child health. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Authors & Co-Authors
Patel, Deven V.
South Africa, Durban
University of Kwazulu-natal
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Bland, Ruth M.
South Africa, Durban
University of Kwazulu-natal
United Kingdom, Glasgow
University of Glasgow
Coovadia, Hoosen Mahomed
South Africa, Durban
Centre for Hiv/aids Networking
Rollins, Nigel Campbell
South Africa, Durban
University of Kwazulu-natal
Coutsoudis, Anna
South Africa, Durban
Centre for Hiv/aids Networking
Newell, Marie Louise
South Africa, Durban
University of Kwazulu-natal
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Statistics
Citations: 67
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1097/QAD.0b013e3283345f91
e-ISSN:
14735571
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Participants Gender
Male
Female