Tuberculosis and HIV co-infection: Clinical trial under the coordination of the Institut Pasteur in Cambodia; [Co-infection tuberculose et VIH: Coordination d'un essai clinique]

Tuberculosis is a major cause of death among adults infected by HIV. The CAMELIA (ANRS 1295/CIPRA KH001) randomized clinical trial aimed to determine the optimal timing of ARV initiation after tuberculosis treatment onset to reduce mortality. Here, we describe the trial implementation in five hospitals in Cambodia under the coordination of the Institut Pasteur in Cambodia, its conduct, the challenges and public health benefits in Cambodia and beyond. © 2013 médecine/sciences - Inserm.