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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Autonomic regulation during orthostatic stress in highlanders: Comparison with sea-level residents
Experimental Physiology, Volume 92, No. 2, Year 2007
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Description
This report is a comparison of orthostatic tolerance and autonomic function in three groups of high-altitude dwellers: Andeans with and without chronic mountain sickness (CMS) and healthy Ethiopians. Results are compared with those from healthy sea-level residents. The aim was to determine whether different high-altitude populations adapted differently to the prevailing hypobaric hypoxia. Orthostatic tolerance was assessed using a test involving head-up tilt (HUT) and graded lower body suction. This was performed at the subjects' resident altitude. Blood pressure (Portapres) and R-R interval (ECG) were recorded during the test, and spectral and cross-spectral analyses of heart period and systolic blood pressure time series were performed using data obtained both while supine and during HUT. The transfer function gain in the low-frequency range (LF, ∼0.1 Hz) at the point of maximal coherence was used as a measure of cardiac baroreflex sensitivity (BRS). As previously reported, Peruvians displayed an unusually good orthostatic tolerance, while Ethiopians showed an orthostatic tolerance comparable to that of healthy sea-level residents. There were no significant differences between groups in the supine values of the spectral analysis results. Head-up tilt induced the expected changes in Ethiopians (an increase in the LF components and a decrease in the respiratory components) but not in Andeans. Cross-spectral analysis showed abnormal results from all groups of high-altitude dwellers. These results indicate that Ethiopians, but not Peruvians, behave similarly to sea-level residents in terms of orthostatic tolerance and autonomic responses to orthostatic stress, as assessed from spectral analyses, and this indicates good adaptation to their environment. However, in all the high-altitude groups the results of cross-spectral analysis were atypical, suggesting some degree of impairment in baroreflex function. © 2007 The Authors.
Authors & Co-Authors
Gulli, Giosué
United Kingdom, Leeds
University of Leeds
Italy, Verona
Università Degli Studi Di Verona
Claydon, Victoria Elizabeth
United Kingdom, Leeds
University of Leeds
Canada, Vancouver
The University of British Columbia
Slessarev, Marat
Canada, Toronto
University of Toronto
Canada, Toronto
Toronto General Hospital
Zenebe, Guta
Ethiopia, Addis Ababa
Addis Ababa University
Gebremedhin, Amha
Ethiopia, Addis Ababa
Addis Ababa University
Rivera-Ch, Maria
Peru, Lima
Universidad Peruana Cayetano Heredia
Appenzeller, Otto
United States, Albuquerque
New Mexico Health Enhancement and Marathon Clinics Research Foundation
Hainsworth, Roger
United Kingdom, Leeds
University of Leeds
Statistics
Citations: 10
Authors: 8
Affiliations: 8
Identifiers
Doi:
10.1113/expphysiol.2006.035519
e-ISSN:
1469445X
Research Areas
Noncommunicable Diseases