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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Are large simple trials for dementia prevention possible?
Age and Ageing, Volume 49, No. 2, Year 2020
Notification
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Description
New trials of dementia prevention are needed to test novel strategies and agents. Large, simple, cardiovascular trials have successfully discovered treatments with moderate but worthwhile effects to prevent heart attack and stroke. The design of these trials may hold lessons for the dementia prevention. Here we outline suitable populations, interventions and outcomes for large simple trials in dementia prevention. We consider what features are needed to maximise efficiency. Populations could be selected by age, clinical or genetic risk factors or clinical presentation. Patients and their families prioritise functional and clinical outcomes over cognitive scores and levels of biomarkers. Loss of particular functions or dementia diagnoses therefore are most meaningful to participants and potential patients and can be measured in large trials. The size of the population and duration of follow-up needed for dementia prevention trials will be a major challenge and will need collaboration between many clinical investigators, funders and patient organisations. © The Author(s) 2019. Published by Oxford University Press on behalf of the British Geriatrics Society.
Authors & Co-Authors
Anand, Sonia S.
Canada, Hamilton
Population Health Research Institute, Ontario
Bangdiwala, Shrikant I.
Canada, Hamilton
Population Health Research Institute, Ontario
Bosch, Jackie J.
Canada, Hamilton
Population Health Research Institute, Ontario
Canavan, M. D.
Ireland, Galway
University of Galway
Gerstein, Hertzel C.
Canada, Hamilton
Population Health Research Institute, Ontario
Canada, Hamilton
Mcmaster University
Gorelick, Philip B.
United States, Chicago
Northwestern University Feinberg School of Medicine
United States, East Lansing
Michigan State University
O'Donnell, Martin J.
Ireland, Galway
University of Galway
Paré, Guillaume
Canada, Hamilton
Population Health Research Institute, Ontario
Pigeyre, Marie
Canada, Hamilton
Population Health Research Institute, Ontario
Seshadri, Sudha S.
United States, Framingham
Framingham Study
United States, Boston
Boston University Chobanian & Avedisian School of Medicine
United States, Austin
University of Texas System
Smith, Eric Edward
Canada, Calgary
University of Calgary
Cukierman-Yaffe, Tali
Israel, Tel Hashomer Tel Aviv
Chaim Sheba Medical Center Israel
Israel, Tel Aviv-yafo
Tel Aviv University
Hart, Robert G.
Canada, Hamilton
Population Health Research Institute, Ontario
Yusuf, Salim N.
Canada, Hamilton
Population Health Research Institute, Ontario
Statistics
Citations: 16
Authors: 14
Affiliations: 16
Identifiers
Doi:
10.1093/ageing/afz152
ISSN:
00020729
Research Areas
Genetics And Genomics
Health System And Policy
Mental Health
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study