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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Amygdala and insula volumes prior to illness onset in bipolar disorder: A magnetic resonance imaging study
Psychiatry Research - Neuroimaging, Volume 201, No. 1, Year 2012
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Description
There are now numerous reports of neuroanatomical abnormalities in people with bipolar disorder. However, it remains unclear whether those abnormalities predate the onset of the illness. In this cross-sectional magnetic resonance imaging study, we assessed 11 young people clinically at ultra-high risk of development of psychosis (UHR), who all developed bipolar I or II disorder by follow-up (median time to onset 328. days - UHR-BP), 11 matched UHR participants, who had no psychiatric diagnosis after at least 12. months of follow-up (UHR-Well) and 11 matched healthy controls (HC). Our main outcome measures were amygdala, hippocampus, insula, lateral ventricular and whole brain volumes. Amygdala and insula volume reductions were more pronounced in the UHR-BP than in the UHR-Well and HC group. Lateral ventricle, whole-brain and hippocampal volumes did not differ between groups. If these findings are confirmed, they suggest that imaging investigations could help to distinguish people who will subsequently develop bipolar disorder from those who will not, at least in symptomatically enriched samples. © 2011 Elsevier Ireland Ltd.
Authors & Co-Authors
Bechdolf, Andreas
Germany, Koln
Universität zu Köln
Australia, Melbourne
Orygen Youth Health
Nelson, Barnaby
Australia, Melbourne
Orygen Youth Health
Yücel, Murat
Australia, Melbourne
Melbourne Health
Yung, Alison R.
Australia, Melbourne
Orygen Youth Health
Berk, Michael
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Australia, Melbourne
The Florey
Pantelis, Christos S.
Australia, Melbourne
Melbourne Health
Australia, Melbourne
The Florey
McGorry, Patrick D.
Australia, Melbourne
Orygen Youth Health
Statistics
Citations: 45
Authors: 7
Affiliations: 9
Identifiers
Doi:
10.1016/j.pscychresns.2011.06.010
ISSN:
18727506
Research Areas
Mental Health
Study Design
Cross Sectional Study
Cohort Study