Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: Role of NADPH oxidase
Cardiovascular Research, Volume 71, No. 4, Year 2006
Notification
URL copied to clipboard!
Description
Objective: Chronic administration of moderate amounts of red wine has been associated with a protective effect on the cardiovascular system. This study examined whether red wine polyphenols prevent the angiotensin II (Ang II)-induced hypertension and endothelial dysfunction in rats, and, if so, to elucidate the underlying mechanism. Methods: Hypertensive rats were obtained by a 14-day infusion of Ang II. Red wine polyphenols were administered in the drinking water one week before and during the Ang II infusion. Arterial pressure was measured in conscious rats. Ex vivo vascular relaxation was assessed in organ chambers, vascular superoxide anion production by dihydroethidine and vascular NADPH oxidase expression by immunohistochemistry. Results: Ang II-induced hypertension was associated with decreased relaxation to acetylcholine but not to red wine polyphenols. The Ang II treatment also increased vascular superoxide anion production and expression of nox1 and p22phox NADPH oxidase subunits. Intake of red wine polyphenols prevented the Ang II-induced hypertension and endothelial dysfunction and normalized vascular superoxide anion production and NADPH oxidase subunit expression. Red wine polyphenol treatment alone did not affect blood pressure. Conclusion: Intake of red wine polyphenols prevents Ang II-induced hypertension and endothelial dysfunction. Prevention of vascular NADPH oxidase induction and preservation of arterial nitric oxide availability during Ang II administration likely contribute to this effect. © 2006 European Society of Cardiology.
Authors & Co-Authors
Sarr, Mamadou Moustapha
France, Paris
Cnrs Centre National de la Recherche Scientifique
Senegal, Dakar
Universite Cheikh Anta Diop Faculte de Medecine et de Pharmacie
Chataigneau, Marta
France, Paris
Cnrs Centre National de la Recherche Scientifique
Martins, Sandrine
France, Paris
Cnrs Centre National de la Recherche Scientifique
Schott, Christa
France, Paris
Cnrs Centre National de la Recherche Scientifique
El Bedoui, Jasser
France, Paris
Cnrs Centre National de la Recherche Scientifique
Oak, Min Ho
South Korea, Icheon
Research and Development Center
Müller, Bernard
France, Paris
Inserm
Chataigneau, Thierry
France, Paris
Cnrs Centre National de la Recherche Scientifique
Schini-Kerth, Valérie Barbara
France, Paris
Cnrs Centre National de la Recherche Scientifique
Statistics
Citations: 177
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1016/j.cardiores.2006.05.022
ISSN:
00086363
Research Areas
Environmental
Noncommunicable Diseases