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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
neuroscience
Acute nicotine treatment prevents rem sleep deprivation-induced learning and memory impairment in rat
Hippocampus, Volume 21, No. 8, Year 2011
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Description
Rapid eye movement (REM) sleep deprivation (SD) is implicated in impairment of spatial learning and memory and hippocampal long-term potentiation (LTP). An increase in nicotine consumption among habitual smokers and initiation of tobacco use by nonsmokers was observed during SD. Although nicotine treatment was reported to attenuate the impairment of learning and memory and LTP associated with several mental disorders, the effect of nicotine on SD-induced learning and memory impairment has not been studied. Modified multiple platform paradigm was used to induce SD for 24 or 48 h during which rats were injected with saline or nicotine (1 mg kg -1 s.c.) twice a day. In the radial arm water maze (RAWM) task, 24- or 48-h SD significantly impaired learning and short-term memory. In addition, extracellular recordings from CA1 and dentate gyrus (DG) regions of the hippocampus in urethane anesthetized rats showed a significant impairment of LTP after 24- and 48-h SD. Treatment of normal rats with nicotine for 24 or 48 h did not enhance spatial learning and memory or affect magnitude of LTP in the CA1 and DG regions. However, concurrent, acute treatment of rats with nicotine significantly attenuated SD-induced impairment of learning and STM and prevented SD-induced impairment of LTP in the CA1 and DG regions. These results show that acute nicotine treatment prevented the deleterious effect of sleep loss on cognitive abilities and synaptic plasticity. © 2010 Wiley-Liss, Inc.
Authors & Co-Authors
Aleisa, Abdulaziz Mohamed A.
Saudi Arabia, Riyadh
College of Pharmacy
Helal, Gouda Kamel
Saudi Arabia, Riyadh
College of Pharmacy
Alhaider, Ibrahim Abdulrahman
United States, Houston
University of Houston
Alzoubi, Karem Hasan
Jordan, Irbid
Jordan University of Science and Technology
Srivareerat, M.
United States, Houston
University of Houston
Tran, T. T.
United States, Houston
University of Houston
Al-Rejaie, Salim Salih
Saudi Arabia, Riyadh
College of Pharmacy
Alkadhi, K. A.
United States, Houston
University of Houston
Statistics
Citations: 88
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1002/hipo.20806
ISSN:
10509631
e-ISSN:
10981063
Research Areas
Environmental
Health System And Policy
Substance Abuse