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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Three-dimensional polycaprolactone scaffold via needleless electrospinning promotes cell proliferation and infiltration
Colloids and Surfaces B: Biointerfaces, Volume 121, Year 2014
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Description
Electrospinning has been widely used in fabrication of tissue engineering scaffolds. Currently, most of the electrospun nanofibers performed like a conventional two-dimensional (2D) membrane, which hindered their further applications. Moreover, the low production rate of the traditional needle-electrospinning (NE) also limited the commercialization. In this article, disc-electrospinning (DE) was utilized to fabricate a three-dimensional (3D) scaffold consisting of porous macro/nanoscale fibers. The morphology of the porous structure was investigated by scanning electron microscopy images, which showed irregular pores of nanoscale spreading on the surface of DE polycaprolactone (PCL) fibers. Protein adsorption assessment illustrated the porous structure could significantly enhance proteins pickup, which was 55% higher than that of solid fiber scaffolds. Fibroblasts were cultured on the scaffold. The results demonstrated that DE fiber scaffold could enhance initial cell attachment. In the 7 days of culture, fibroblasts grew faster on DE fiber scaffold in comparison with solid fiber, solvent cast (SC) film and TCP. Fibroblasts on DE fibers showed a stretched shape and integrated with the porous surface tightly. Cells were also found to migrate into the DE scaffold up to 800. μm. Results supported the use of DE PCL fibers as a 3D tissue engineering scaffold in soft tissue regeneration. © 2014 Elsevier B.V.
Authors & Co-Authors
Li, Dawei
China, Shanghai
Donghua University
Wu, Tong
China, Shanghai
Donghua University
He, Nanfei
China, Shanghai
Donghua University
Wang, Jing
China, Shanghai
Donghua University
Chen, Weiming
China, Shanghai
Donghua University
He, Liping
China, Shanghai
Donghua University
Huang, Chen
China, Shanghai
Donghua University
El-Hamshary, Hany
Saudi Arabia, Riyadh
College of Sciences
Egypt, Tanta
Faculty of Science
Al-Deyab, Salem Salem
Saudi Arabia, Riyadh
College of Sciences
Ke, Qinfei
China, Shanghai
Donghua University
China, Shanghai
Shanghai Normal University
Mo, Xiumei
China, Shanghai
Donghua University
Statistics
Citations: 11
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1016/j.colsurfb.2014.06.034
ISSN:
09277765
e-ISSN:
18734367