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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Characterization of the antiproliferative activity of Xylopia aethiopica
Cell Division, Volume 7, Article 8, Year 2012
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Description
Background: Xylopia aethiopica, a plant found throughout West Africa, has both nutritional and medicinal uses. The present study aims to characterize the effects of extracts of this plant on cancer cells.Results: We report that X. aethiopica extract prepared with 70% ethanol has antiproliferative activity against a panel of cancer cell lines. The IC50 was estimated at 12 μg/ml against HCT116 colon cancer cells, 7.5 μg/ml and > 25 μg/ml against U937 and KG1a leukemia cells, respectively. Upon fractionation of the extract by HPLC, the active fraction induced DNA damage, cell cycle arrest in G1 phase and apoptotic cell death. By using NMR and mass spectrometry, we determined the structure of the active natural product in the HPLC fraction as ent-15-oxokaur-16-en-19-oic acid.Conclusion: The main cytotoxic and DNA-damaging compound in ethanolic extracts of Xylopia aethiopica is ent-15-oxokaur-16-en-19-oic acid. © 2012 Choumessi et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Choumessi, Aphrodite Tchewonpi
Cameroon, Yaounde
Université de Yaoundé I
Danel, Mathieu
France, Toulouse
Université Fédérale Toulouse Midi-pyrénées
France, Paris
Cnrs Centre National de la Recherche Scientifique
Chassaing, Stefan
France, Toulouse
Université Fédérale Toulouse Midi-pyrénées
France, Paris
Cnrs Centre National de la Recherche Scientifique
Truchet, Isabelle
France, Toulouse
Université Fédérale Toulouse Midi-pyrénées
France, Paris
Cnrs Centre National de la Recherche Scientifique
Penlap, Véronique B.
Cameroon, Yaounde
Université de Yaoundé I
Pieme, Anatole Constant
Cameroon, Yaounde
Université de Yaoundé I
Asonganyi, Tazoacha
Cameroon, Yaounde
Université de Yaoundé I
Ducommun, Bernard
France, Toulouse
Université Fédérale Toulouse Midi-pyrénées
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Toulouse
Chu de Toulouse
France, Toulouse
Itav - Centre Pierre Potier
Valette, Annie
France, Toulouse
Université Fédérale Toulouse Midi-pyrénées
France, Paris
Cnrs Centre National de la Recherche Scientifique
Statistics
Citations: 57
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1186/1747-1028-7-8
e-ISSN:
17471028
Research Areas
Cancer
Genetics And Genomics
Study Locations
Multi-countries