Anti-hyperglycemic efficacy of derris ovalifolia in alloxan-induced diabetic wister rats

Diabetes has been characterized by abnormal glucose homeostasis arising from various pathogenic mechanisms involving β-cells dysfunction that results in hyperglycemia. Despite latest advancement for the treatment of diabetes, numerous challenges are still come across regarding use of available drugs and their complications. Current study was designed to assess the anti-hyperglycemic effects of Derris ovalifolia in diabetic rats. For this purpose, methanolic extract of D. ovalifolia was administered in graded doses (400 & 600 mg/kg body weight) to alloxan-induced diabetic rat model for a period of 4 weeks. Qualitative, quantitative phytochemical analysis, proximate composition and DPPH assay of methanolic extract of D. ovalifolia were performed. Blood samples were collected for monitoring glucose level, serum insulin level and other biochemical parameters. The data were subjected to statistical analysis by applying ANOVA and DMR. Significant anti-hyperglycemic effect was observed by reducing serum glucose and increasing serum insulin level in comparison to positive diabetic group. Treatment with methanolic extract of D. ovalifolia also led to improvement in serum amylin, glucokinase (GCK) and leptin.