Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
NGP1-01, a lipophilic polycyclic cage amine, is neuroprotective in focal ischemia
Neuroscience Letters, Volume 383, No. 1-2, Year 2005
Notification
URL copied to clipboard!
Description
NGP1-01, a member of the pentacycloundecylamine cage compound family, was recently shown to exhibit both NMDA receptor channel blocking and L-type calcium channel antagonism activity. In the present study, focal ischemia was induced in mice by permanent middle cerebral artery occlusion (MCAO) to test for potential neuroprotective properties of the compound. In female CD-1 mice injected 30 min before MCAO, NGP1-01 (20 mg/kg) reduced infarct area by 42.6% (P < 0.05) compared to vehicle-treated controls as visualized by 2,3,5-triphenyltetrazolium chloride (TTC) staining. Concomitantly, NGP1-01 reduced brain swelling by 78.3% (P < 0.001), compared to vehicle (DMSO) treated controls. These data identify NGP1-01 and related compounds as potential lead structures to develop neuroprotective compounds based on a dual mechanism of action. © 2005 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Mdzinarishvili, Alexander
United States, Amarillo
Texas Tech University Health Sciences Center at Amarillo
Geldenhuys, Werner J.
United States, Amarillo
Texas Tech University Health Sciences Center at Amarillo
South Africa, Potchefstroom
North-west University
Abbruscato, Thomas J.
United States, Amarillo
Texas Tech University Health Sciences Center at Amarillo
Bickel, Ulrich
United States, Amarillo
Texas Tech University Health Sciences Center at Amarillo
Klein, Jochen
United States, Amarillo
Texas Tech University Health Sciences Center at Amarillo
van der Schyf, Cornelis J.
United States, Amarillo
Texas Tech University Health Sciences Center at Amarillo
South Africa, Potchefstroom
North-west University
Statistics
Citations: 72
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.neulet.2005.03.042
Participants Gender
Female