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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Dioxin sensitivity-related two critical amino acids of arylhydrocarbon receptor may not correlate with the taxonomy or phylogeny in avian species
Journal of Veterinary Medical Science, Volume 75, No. 12, Year 2013
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Description
There are two arylhydrocarbon receptor (AhR) isoforms in birds, AhR1 and AhR2. The varying sensitivity of AhR is reported to be related to two critical amino acids at positions 325 and 381 in the AhR1 ligand-binding domain. In this study, seven avian species whose in vivo dioxin sensitivity was known, and 13 species with no data regarding their in vivo dioxin sensitivity were examined. The two critical amino acids in the ligand-binding domain were investigated in avian species, and the results were compared with the taxonomy or phylogenetic trees for the bird AhR proteins. We found that the two critical amino acids did not correlate with the taxonomy or phylogeny of these proteins, suggesting that dioxin sensitivity was independent of taxonomy. ©2013 The Japanese Society of Veterinary Science.
Authors & Co-Authors
Fujisawa, Nozomi
Japan, Sapporo
Hokkaido University
Kawai, Yusuke K.
Japan, Sapporo
Hokkaido University
Japan, Sapporo
Graduate School of Medicine
Nakayama, Shouta M.
Japan, Sapporo
Hokkaido University
Ikenaka, Yoshinori
Japan, Sapporo
Hokkaido University
Ishizuka, Mayumi
Japan, Sapporo
Hokkaido University
Statistics
Citations: 5
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1292/jvms.13-0179
ISSN:
13477439