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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Diversity of response to Trypanosoma brucei gambiense infections in the Forecariah mangrove focus (Guinea): Perspectives for a better control of sleeping sickness
Microbes and Infection, Volume 13, No. 11, Year 2011
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Description
At a time when human African trypanosomiasis (HAT) elimination again seems a reachable goal in many parts of sub-Saharan Africa, it is becoming increasingly important to characterise the factors involved in disease resurgence or maintenance to develop sustainable control strategies. In this study conducted in the Forecariah mangrove focus in Guinea, HAT patients and serological suspects (SERO) were identified through mass screening of the population with the Card Agglutination Test for Trypanosomiasis (CATT) and were followed up for up to 2 years. Analysis of the samples collected during the follow-up of HAT patients and SERO was performed with PCR (TBR1/TBR2) and the trypanolysis serological test (TL) in order to clarify the role played by these individuals in the epidemiology of HAT. PCR positivity was higher in TL + than in SERO TL - (50% vs. 18%, respectively). Whereas CATT plasma titres decreased both in treated HAT patients and SERO TL -, SERO TL + maintained high CATT titres. Four out of 17 SERO TL + developed HAT during the study. These results strongly suggest that SERO TL + individuals are asymptomatic carriers. In the context where disease prevalence is sufficiently low, treating SERO TL + individual may thus be of crucial importance in order to cut transmission. © 2011 Institut Pasteur.
Authors & Co-Authors
Ilboudo, Hamidou
Burkina Faso
Centre International de Recherche-développement Sur L'elevage en Zones Subhumides Cirdes
France, Montpellier
Ird Centre de Montpellier
Jamonneau, Vincent
Burkina Faso
Centre International de Recherche-développement Sur L'elevage en Zones Subhumides Cirdes
France, Montpellier
Ird Centre de Montpellier
Camara, Mamadou I.
Guinea
Programme National de Lutte Contre la Trypanosomose Humaine Africaine
Camara, Oumou B.
Guinea
Programme National de Lutte Contre la Trypanosomose Humaine Africaine
Dama, Emilie
Burkina Faso
Centre International de Recherche-développement Sur L'elevage en Zones Subhumides Cirdes
France, Montpellier
Ird Centre de Montpellier
Léno, Mamadou
Guinea
Programme National de Lutte Contre la Trypanosomose Humaine Africaine
Ouendeno, Frédéric F.
Guinea
Programme National de Lutte Contre la Trypanosomose Humaine Africaine
Courtin, Fabrice
Burkina Faso
Centre International de Recherche-développement Sur L'elevage en Zones Subhumides Cirdes
France, Montpellier
Ird Centre de Montpellier
Sakandé, Hassane
Burkina Faso
Centre International de Recherche-développement Sur L'elevage en Zones Subhumides Cirdes
Sanon, René
France, Montpellier
Ird Centre de Montpellier
Kaboré, Jacques
Burkina Faso
Centre International de Recherche-développement Sur L'elevage en Zones Subhumides Cirdes
France, Montpellier
Ird Centre de Montpellier
Coulibaly, Bamoro
Cote D'ivoire, Bouake
Institut Pierre Richet Bouake
N'Dri, Louis
Cote D'ivoire, Bouake
Institut Pierre Richet Bouake
Diarra, Abdoulaye
Switzerland, Geneva
Organisation Mondiale de la Santé
N'Goran, Eliézer Kouakou
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Bucheton, Bruno
Burkina Faso
Centre International de Recherche-développement Sur L'elevage en Zones Subhumides Cirdes
France, Montpellier
Ird Centre de Montpellier
Statistics
Citations: 44
Authors: 16
Affiliations: 6
Identifiers
Doi:
10.1016/j.micinf.2011.05.007
ISSN:
12864579
e-ISSN:
1769714X
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Guinea