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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Breast cancer and human papillomavirus infection: No evidence of HPV etiology of breast cancer in Indian women
BMC Cancer, Volume 11, Article 27, Year 2011
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Description
Background: Two clinically relevant high-risk HPV (HR-HPV) types 16 and 18 are etiologically associated with the development of cervical carcinoma and are also reported to be present in many other carcinomas in extra-genital organ sites. Presence of HPV has been reported in breast carcinoma which is the second most common cancer in India and is showing a fast rising trend in urban population. The two early genes E6 and E7 of HPV type 16 have been shown to immortalize breast epithelial cells in vitro, but the role of HPV infection in breast carcinogenesis is highly controversial. Present study has therefore been undertaken to analyze the prevalence of HPV infection in both breast cancer tissues and blood samples from a large number of Indian women with breast cancer from different geographic regions.Methods: The presence of all mucosal HPVs and the most common high-risk HPV types 16 and 18 DNA was detected by two different PCR methods - (i) conventional PCR assays using consensus primers (MY09/11, or GP5+/GP6+) or HPV16 E6/E7 primers and (ii) highly sensitive Real-Time PCR. A total of 228 biopsies and corresponding 142 blood samples collected prospectively from 252 patients from four different regions of India with significant socio-cultural, ethnic and demographic variations were tested.Results: All biopsies and blood samples of breast cancer patients tested by PCR methods did not show positivity for HPV DNA sequences in conventional PCRs either by MY09/11 or by GP5+/GP6+/HPV16 E6/E7 primers. Further testing of these samples by real time PCR also failed to detect HPV DNA sequences.Conclusions: Lack of detection of HPV DNA either in the tumor or in the blood DNA of breast cancer patients by both conventional and real time PCR does not support a role of genital HPV in the pathogenesis of breast cancer in Indian women. © 2011 Hedau et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Hedau, Suresh
India, Noida
Institute of Cytology and Preventive Oncology Icmr
Kumar, Umesh
India, Noida
Institute of Cytology and Preventive Oncology Icmr
Hussain, Showket
India, Noida
Institute of Cytology and Preventive Oncology Icmr
Shukla, Shirish
India, Noida
Institute of Cytology and Preventive Oncology Icmr
Pande, Shailja
India, Noida
Institute of Cytology and Preventive Oncology Icmr
Jain, Neeraj
India, Noida
Institute of Cytology and Preventive Oncology Icmr
Tyagi, Abhishek
India, Noida
Institute of Cytology and Preventive Oncology Icmr
Deshpande, Trivikram
India, Taleigao
Goa University
Bhat, Dilafroze
India, Srinagar
Sher-i-kashmir Institute of Medical Sciences
Mir, Mohammad Muzaffar
Saudi Arabia, Sakaka
Al-souf University Sakaka
Chakraborty, Sekhar
India, Silchar
Silchar Medical College
Singh, Y. Mohan
India, Imphal
Regional Institute of Medical Science
Kumar, Rakesh
India, New Delhi
Dr. B.r. Ambedkar Center for Biomedical Research
Somasundaram, Kumaravel
India, Bengaluru
Indian Institute of Science
Bharti, Alok C.
India, Noida
Institute of Cytology and Preventive Oncology Icmr
Das, B. C.
India, Noida
Institute of Cytology and Preventive Oncology Icmr
India, New Delhi
Dr. B.r. Ambedkar Center for Biomedical Research
Statistics
Citations: 74
Authors: 16
Affiliations: 8
Identifiers
Doi:
10.1186/1471-2407-11-27
e-ISSN:
14712407
Research Areas
Cancer
Genetics And Genomics
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Participants Gender
Female