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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Selenium and other mineral elements in populations at risk for esophageal cancer
Cancer, Volume 62, No. 12, Year 1988
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Description
The current study tested the hypothesis that deficiencies of certain mineral elements are risk factors for esophageal cancer (EC). In rural blacks living in areas with moderate to high EC incidence rates in southern Africa, the whole blood selenium (Se) levels were found to be significantly (P < 0.0005) lower (58 to 71 ng/ml) than those of rural and urban populations living in low EC rate areas (114 to 177 ng/ ml). No significant differences were found in the plasma levels of the other mineral elements examined, including zinc, copper, and magnesium. Within a high EC rate area occupants of households with previously recorded EC cases had significantly (P < 0.0025) lower levels of Se (64 ng/ml), but not of other mineral elements, than subjects from households without known cases (77 ng/ml). Mean Se levels of subjects with premalignant or malignant esophageal cytological changes (54 ng/ml) were significantly (P < 0.0025) lower than those of subjects without such lesions (68 ng/ml). An inverse relationship was found between Se status and the degree of cytologic abnormality. These findings suggest that Se deficiency may play a role in the development of EC. The potential value of whole blood Se determinations and esophageal cytologic examinations in the early detection and of Se supplementation in the prevention of EC merits further investigation. Copyright © 1988 American Cancer Society
Authors & Co-Authors
Jaskiewicz, Kasimir
South Africa, Tygerberg
South African Medical Research Council
Marasas, W. F. O.
South Africa, Tygerberg
South African Medical Research Council
Rossouw, Jacques E.
South Africa, Tygerberg
South African Medical Research Council
van Niekerk, F. E.
Unknown Affiliation
Tech, E. W.P.Heine
South Africa, Stellenbosch
Regional Veterinary Laboratory
Statistics
Citations: 57
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1002/1097-0142(19881215)62:12<2635::AID-CNCR2820621232>3.0.CO;2-5
ISSN:
0008543X
e-ISSN:
10970142
Research Areas
Cancer
Study Design
Cohort Study