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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Synthesis and investigation of anti-inflammatory activity and gastric ulcerogenicity of novel nitric oxide-donating pyrazoline derivatives
European Journal of Medicinal Chemistry, Volume 44, No. 7, Year 2009
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Description
A group of 3,5-diaryl-2-pyrazoline derivatives were prepared via the reaction of various chalcones with hydrazine hydrate in ethanol. A group of NO-donating-2-pyrazoline derivatives were synthesized by carrying a nitrate ester group or an oxime group onto the prepared pyrazoline derivatives through different spacers. The prepared compounds were evaluated for their anti-inflammatory activity using carrageenan-induced rat paw edema and compared to a well-known NSAID, indomethacin as a reference drug. The ability of the prepared compounds to induce gastric toxicity was also evaluated. Most of the prepared compounds showed significant anti-inflammatory activity at the injected dose (100 mg/kg) but they were safer than indomethacin in regard to gastric toxicity. The incorporation of the NO-donating group into the parent pyrazoline derivatives caused a non-significant reduction in the anti-inflammatory activity while a marked decrease in gastric ulcerations induced by their parent pyrazolines was observed. © 2008 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Shoman, Mai E.
Egypt, Minya
Faculty of Pharmacy
Abdel-Aziz, Mohamed R.
Egypt, Minya
Faculty of Pharmacy
Aly, Omar M.
Egypt, Minya
Faculty of Pharmacy
Farag, Hassan H.A.
Egypt, Asyut
Faculty of Pharmacy
Morsy, Mohamed Aly
Egypt, Minya
Faculty of Medicine
Statistics
Citations: 71
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.ejmech.2008.07.008
ISSN:
02235234
e-ISSN:
17683254