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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Outcomes of pediatric bone marrow transplantation for leukemia and myelodysplasia using matched sibling, mismatched related, or matched unrelated donors
Blood, Volume 116, No. 19, Year 2010
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Description
Although some trials have allowed matched or single human leukocyte antigen (HLA)-mismatched related donors (mmRDs) along with HLA-matched sibling donors (MSDs) for pediatric bone marrow transplantation in early-stage hematologic malignancies, whether mmRD grafts lead to similar outcomes is not known.We compared patients < 18 years old reported to the Center for International Blood and Marrow Transplant Research with acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, and myelodysplastic syndrome undergoing allogeneic T-replete, myeloablative bone marrow transplantation between 1993 and 2006. In total, patients receiving bone marrow from 1208 MSDs, 266 8/8 allelic-matched unrelated donors (URDs), and 151 0-1 HLA-antigen mmRDs were studied. Multivariate analysis showed that recipients of MSD transplants had less transplantation-related mortality, acute graft-versus-host disease (GVHD), and chronic GVHD, along with better disease-free and overall survival than the URD and mmRD groups. No differences were observed in transplant-related mortality, acute and chronic GVHD, relapse, disease-free survival, or overall survival between the mmRD and URD groups. These data show that mmRD and 8/8 URD outcomes are similar, whereas MSD outcomes are superior to the other 2 sources. Whether allele level typing could identify mmRD recipients with better outcomes will not be known unless centers alter practice and type mmRD at the allele level. © 2010 by The American Society of Hematology.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2981549/bin/blood-2010-01-261958_index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC2981549/bin/blood-2010-01-261958_1.pdf
Authors & Co-Authors
Shaw, Peter John
Unknown Affiliation
Kan, Fangyu
Unknown Affiliation
Ahn, Kwang Woo
Unknown Affiliation
Spellman, Stephen R.
Unknown Affiliation
Aljurf, Mahmoud Deeb
Unknown Affiliation
Ayas, Mouhab Fakhreddine
Unknown Affiliation
Burke, Michael
Unknown Affiliation
Cairo, Mitchell S.
Unknown Affiliation
Chen, A. R.
Unknown Affiliation
Davies, Stella M.
Unknown Affiliation
Frangoul, Haydar A.
Unknown Affiliation
Gajewski, James
Unknown Affiliation
Gale, Robert Peter
Unknown Affiliation
Godder, Kamar
Unknown Affiliation
Hale, Gregory A.
Unknown Affiliation
Heemskerk, Martin B.A.
Unknown Affiliation
Horan, John T.
Unknown Affiliation
Kamani, Nayesh R.
Unknown Affiliation
Kasow, Kimberly A.
Unknown Affiliation
Chan, Ka Wah
Unknown Affiliation
Lee, Stephanie Joi
Unknown Affiliation
Leung, Wing H.
Unknown Affiliation
Lewis, Victor Anthony
Unknown Affiliation
Miklos, David
Unknown Affiliation
Oudshoorn, Machteld
Unknown Affiliation
Petersdorf, Effie Wang
Unknown Affiliation
Ringdén, Oolle T.H.
Unknown Affiliation
Sanders, Jean
Unknown Affiliation
Schultz, Kirk R.
Unknown Affiliation
Seber, Adriana
Unknown Affiliation
Setterholm, Michelle
Unknown Affiliation
Wall, Donna A.
Unknown Affiliation
Pulsipher, Michael A.
Unknown Affiliation
Statistics
Citations: 99
Authors: 33
Affiliations: 30
Identifiers
Doi:
10.1182/blood-2010-01-261958
ISSN:
00064971
Research Areas
Genetics And Genomics